荜茇水提取物对小鼠胃排空和肠推进的影响

目的:研究荜茇水提取物对小鼠肠推进和胃排空的影响。方法:荜茇水提取物灌胃给药6天,采用小肠炭末推进实验观察荜茇水提取物对正常小鼠小肠运动及硫酸阿托品所致小鼠小肠抑制模型的影响,采用甲基橙胃残留率的方法观察荜茇水提取物对正常小鼠胃排空的影响。结果:荜茇水提取物20g/kg和10g/kg可促进正常小鼠小肠运动,并能明显拮抗硫酸阿托品所致小鼠小肠抑制作用,荜茇水提取物20g生药/kg和10g生药/kg可促进正常小鼠胃排空。结论:荜茇水提取物对正常小鼠小肠运动及硫酸阿托品所致小鼠小肠抑制均有明显促进作用,并对正常小鼠胃排空有促进作用,其机制可能与M胆碱受体有关。

Effect of Piper longum L.on gastric emptying and intestinal propulsive function in mice

Object:To study the effect of Piper longum L.on gastric emptying and intestinal propulsive function in mice.Methods:20g/kg,10g/kg and 5 g/kg of Piper longum L.were taken by mice for 6 days.Charcoal as a marker was orally administered to determine the propulsive function of small intestine.The effects of Piper longum L.were observed in normal mice and mice pretreated with atropine sulphate injection.Used the phenol red methods to assay gastric emptying.Results:Piper longum L.20g/kg and 10g/kg significantly improved the propulsive function of small intestine in both normal mice and mice pretreated with atropine sulphate injection in a dose-dependent manner.Piper longum L.20g/kg and 10g/kg quicken the rate of gastric emptying in normal mice.Conclusion:Piper longum L.quickens the rate of gastric emptying in normal mice and improves the propulsive function of small intestine,and the mechanism of action probably via an action on the cholinergic receptor.