脑立苏冲剂对脑缺血模型大鼠的影响

【目的】观察脑立苏冲剂对实验性脑缺血模型大鼠的影响。【方法】采用大脑中动脉栓塞法复制大鼠脑缺血模型，观察脑立苏冲剂对脑缺血模型大鼠脑含水量的影响；采用比色法测定大鼠脑内伊文思蓝含量，观察该药对脑缺血大鼠脑组织血管通透性的影响，采用苏木素一伊红（HE）染色观察该药对模型大鼠脑组织形态结构改变的影响。【结果】脑立苏冲剂能改善缺血脑组织毛细血管通透性、减轻脑水肿，与缺血模型组比较有显著性差异（均P〈0．01），其作用与维脑路通相仿。【结论】脑立苏冲剂具有增加脑血流量，减轻脑含水量，降低毛细血管通透性，改善组织形态结构的作用．其治疗脑缺血疾病的疗效可能与此有关。

Effects of Naolisu Granules on the Rat Models with Cerebral Ischemia

[Objective] To observe the effect of Naolisu Granules (NG) for experimental cerebral ischemia in rats. [Methods] Rat models with cerebral ischemia was set up by embolization of middle artery. To observe the effects of NG on cerebrovascular permeability, cerebral water content was examined and cerebral Evans blue (EB) content was detected with chromatometry. Meanwhile, the effect of HG on cerebral histological structure was observed with hematoxylin and eosin(HE) staining method. [Results] NG decreased cerebral capillary permeability and cerebral edema ( P <0.01 compared with the model group), which was similar to Weinaalutong Granules. [Conclusion] NG has an effect on increasing cerebral blood flow, reducing cerebral water content, decreasing cerebral capillary permeability and improving histological features. This may be the therapeutic mechanism of NG for cerebral ischemia.