Visfatin研究进展

Visfatin是新发现的一种脂肪细胞因子,主要来源于内脏脂肪组织.Visfatin可促进脂肪蓄积,有类胰岛素样作用,并在促进炎性反应因子表达及诱导血管生成方面发挥一定作用.多项研究表明,visfatin在肥胖、糖尿病、代谢综合征等代谢性疾病患者及冠心病等心血管疾病患者体内表达水平均有不同程度增加,同时visfatin与多囊卵巢综合征、非酒精性脂肪肝等疾病密切相关.目前研究显示visfatin是细胞内烟酰胺磷酸核糖转移酶(Nampt)的细胞外形式,其复杂作用机制或许能完全用Nampt的作用来解释,这为肥胖、糖尿病、心血管疾病等提供了新的治疗方向.

Recent progress of visfatin

Visfatin, a novel adipocytokine, is mainly released from visceral adipose tissue. Visfatin can promote fat accumulation, have insulin-like role, and play a role in promoting the expression of inflamma-tory cytokines and induction of angiogenesis. A number of studies show that visfatin is higher in patients with metabolic disorders, such as obesity, diabetes, metabolic syndrome and so on, as well as in patients with cardi-ovascular disease such as coronary heart disease and so on. The studies also found that visfatin is closely re-lated to polycystic ovarian syndrome, nonalcoholic fatty liver disease. Current studies have shown that visfatin is the extracellular form of nicotinamide phosphofibosyl transferase (Nampt). The role of Nampt might be a-ble to fully explain the complex mechanism of visfatin. This idea provides a new therapeutic direction for obe-sity, diabetes, cardiovascular diseases and so on.