| ER、PR、C-erbB-2和Ki-67在乳腺癌新辅助化疗前后中的表达及意义 |
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| 引用本文： | 姚永强,曹铭谦,张殿龙,方红,解继平.ER、PR、C-erbB-2和Ki-67在乳腺癌新辅助化疗前后中的表达及意义[J].中国现代药物应用,2009,3(23):9-11. |
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| 作者姓名： | 姚永强 曹铭谦 张殿龙 方红 解继平 |
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| 作者单位： | 大连大学附属中山医院普外三科,116001 |
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| 摘 要： | 目的探讨新辅助化疗（NAC）对乳腺癌组织中雌激素受体（estrogen receptor，ER）、孕激素受体（progesterone receptor，PR）C-erbB．2和Ki-67表达及意义。方法采用免疫组化S-P法检测化疗前后56例乳腺癌组织中ER、PR、C-erbB-2和Ki-67的表达。结果新辅助化疗前后ER、PR和C-erbB-2的表达无明显变化（P〉0．05）。新辅助化疗前后Ki-67的表达差异有统计学意义（P〈0．05）。结论新辅助化疗能显著降低Ki-67的表达，对ER、PR和C-erbB-2的表达状态无明显影响。新辅助化疗后检测可为后续治疗和判断预后提供指导。
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| 关 键 词： | 乳腺肿瘤 新辅助化疗 ER PR C-erbB-2 Ki-67 |
Expression and significance of ER,PR,C-erbB-2 and Ki-67 before and after neo-adjuvant chemotherapy in breast cancer |
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| Institution: | YAO Yong-qiang, CAO Ming-qian, ZHANG Dian-long, et al.( Zhongshan Hospital of Dalian U- niversity of P outside the three branches 116001, China) |
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| Abstract: | Objective To study the expression and significance of ER,PR, C-erbB-2 and Ki-67 before and after neo-adjuvant chemotherapy in patients with breast cancer. Methods The immunohistochemical staining method was used to examine the expression of ER, PR, C-erbB-2 and Ki-67. Results The expression of ER,PR and C-erbB-2 had no significant difference after neo-adjuvant chemotherapy as compared with before neo-adjuvant chemotherapy （ P 〉 0. 05 ）. The expression of Ki-67 significantly difference after neo-adjuvant chemotherapy as compared with before neo-adjuvant chemotherapy（ P 〈 0. 05 ）. Conclusion The expression of Ki-67 is decreased after neo-adjuvant chemotherapy. Neo-adjuvant chemotherapy has no significant influence on the expression of ER,PR and C-erbB-2. |
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| Keywords: | ER PR C-erbB-2 Ki-67 |
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