Analysis of microsatellite instability in laryngeal squamous cell carcinoma |
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Authors: | García Martínez Jorge Pérez-Escuredo Jhudit García-Carracedo Dario Alonso-Guervós Marta Suárez-Nieto Carlos Llorente-Pendás José Luis Alvarez-Marcos César Hermsen Mario |
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Institution: | Departamento de Otorrinolaringología, IUOPA, Hospital Universitario Central de Asturias, Oviedo, Asturias, España |
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Abstract: | Introduction and objectivesThe literature on the involvement of microsatellite instability in head and neck squamous cell carcinoma shows great variability, probably due to differences in the testing methods. Using a consensus detection system, we aimed to reach a reliable estimate of microsatellite instability prevalence in a subset of head and neck squamous cell carcinoma cases.MethodsThe microsatellite instabilityI status of 43 patients with previously untreated primary laryngeal squamous cell carcinomas was analyzed by a multiplex polymerase chain reaction assay including 5 mononucleotide repeat markers.ResultsThirty-six cases showed a stable phenotype or a microsatellite stable phenotype (83.7%) and 7 cases (16.3%) showed an microsatellite instability-positive phenotype. One case showed instability in 3 of 5 markers, 1 case in 2 markers and 5 cases in 1 marker. The microsatellite instability-positive and stable cases did not differ with respect to age, tumour stage, lymph node or distant metastases.ConclusionsOur data showed that a proportion of laryngeal squamous cell carcinomas are microsatellite instability positive. Knowledge of microsatellite instability patient status will allow adjusting anticancer therapy at an individual level. |
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