Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. |
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| Authors: | K Podar Y T Tai F E Davies S Lentzsch M Sattler T Hideshima B K Lin D Gupta Y Shima D Chauhan C Mitsiades N Raje P Richardson K C Anderson |
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| Institution: | Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM. |
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