| 胆囊收缩素－B受体拮抗剂的镇痛作用 |
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| 引用本文： | 陈泓,张开镐. 胆囊收缩素－B受体拮抗剂的镇痛作用[J]. 中国药物依赖性杂志, 1996, 0(3) |
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| 作者姓名： | 陈泓 张开镐 |
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| 作者单位： | 北京医科大学第三临床医学院心血管研究所，北京医科大学中国药物依赖性研究所 |
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| 摘 要： | 用小鼠热水缩尾法研究了高选择性的ＣＣＫ－Ｂ受体拮抗剂ＰＤ１３４３０８的镇痛效应。ＰＤ１３４３０８在小鼠产生的镇痛有剂量依赖关系。阿片受体拮抗剂对抗其镇痛作用，表明阿片受体系统参与介导ＰＤ１３４３０８的镇痛。ＰＤ１３４３０８能加强吗啡的镇痛作用，但对α２受体激动剂可乐定的镇痛作用没有影响，表明ＣＣＫ－Ｂ受体拮抗剂对阿片受体系统作用有选择性。脑啡肽酶抑制剂ＳＣＨ３２６１５加强ＰＤ１３４３０８的镇痛作用，说明ＰＤ１３４３０８可能是通过增加内源性阿片物质产生镇痛作用的。另外，ＰＤ１３４３０８还参与吗啡镇痛耐受性的形成。
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| 关 键 词： | 胆囊收缩素－B受体拮抗剂，镇痛作用，阿片受体 |
ANALGESIC EFFECT OF A CCK - B ANTAGONIST |
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| . Chen Hong, Zhang Kaigao. ANALGESIC EFFECT OF A CCK - B ANTAGONIST[J]. Chinese Journal of Drug Dependence, 1996, 0(3) |
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| Authors: | . Chen Hong Zhang Kaigao |
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| Affiliation: | . Chen Hong, Zhang Kaigao1 |
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| Abstract: | An analgesic effect of PD134308 was studied in mice using a 50℃warm water tail - withdrawal assay. PD134308 produced analgesia dose - dependently(10 - 320 mg· kg -1). The analgesia induced by PD134308 was antagonized by naltrexone, but potentiated by SCH 32615, an enkephalinase inhibitor. The analgesic effect ofmorphine was enhanced by PD 134308, but attenuated by CCK - 4. However, PD 134308had no ettect on the clonidine - induced analgesia. These data suggest that PD 134308induced analgesia could be produced through an augmentation of endogenous opioids. |
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| Keywords: | CCK - B antagonist analgesia opioid |
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