| 左旋精氨酸对缺血—再灌注损伤肝脏的保护作用 |
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| 引用本文： | 王万铁 徐正介 王卫,李东 林丽娜 王宗敏.左旋精氨酸对缺血—再灌注损伤肝脏的保护作用[J].中华肝脏病杂志,2000,8(6):370-372. |
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| 作者姓名： | 王万铁 徐正介 王卫 李东 林丽娜 王宗敏 |
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| 作者单位： | 王万铁（温州医学院病理生理教研室 温州，325003）;徐正介（温州医学院病理生理教研室 温州，325003）;王卫（温州医学院病理生理教研室 温州，325003）;李东（检验系分析中心）;林丽娜（温州医学院附属第一医院麻醉科）;王宗敏（温州医学院附属第二医院病理科） |
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| 基金项目： | 浙江省卫生厅科研基金（NO.98A087） |
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| 摘 要： | 目的探讨左旋精氨酸（L-arginine，L-Arg）对肝缺血－再灌注损伤（hepaticischemia-reperfusioninjury，HIRI）的防治作用及其机理。方法选择HIRI家兔及肝手术患者，观察一氧化氮水平、丙二醛浓度、血栓素B
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| 关 键 词： | 肝缺血 再灌注损伤 左旋精氨酸 防治 |
| 修稿时间： | 1999年11月8日 |
Protective effect of
L-arginine on liver during ischemia-reperfusion injury |
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| WANG Wantie.Protective effect of
L-arginine on liver during ischemia-reperfusion injury[J].Chinese Journal of Hepatology,2000,8(6):370-372. |
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| Authors: | WANG Wantie |
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| Institution: | Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325003, China. |
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| Abstract: | OBJECTIVE: To explore the protective effect of L-arginine (L-Arg) on liver during hepatic ischemia-reperfusion injury (HIRI) and its mechanisms. METHODS: Changes of several parameters, including nitric oxide (NO), malondiadehyde (MDA), thromboxane B(2) ( TXB(2) ), 6-keto-prostaglandin F(1-alpha) (6-keto-PGF(1-alpha) ), TXB(2) / 6-keto-PGF(1-alpha) ( T / K ) and alanine aminotransferase (ALT) as well as liver morphological changes, and the effect of L-Arg on them were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery. RESULTS: The levels of NO and 6-keto-PGF(1-alpha) decreased remarkably. MDA concentration, TXB(2) content and T / K ratio as well as ALT activity increased significantly. The morphological changes of hepatocytes were obvious during HIRI. After treatment with L-Arg, the variations of all the parameters were markedly alleviated. CONCLUSION: L-Arg possess preventive effects on HIRI by raising NO and reducing MDA as well as correcting TXA(2) / PGI(2) imbalance after hepatic ischemia-reperfusion. |
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