Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using indocyanine green fluorescence imaging |
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Authors: | Ahmed Al-Dam Clarissa Precht Armelle Barbe Carsten Kohlmeier Henning Hanken Johannes Wikner Gerhard Schön Max Heiland Alexandre T Assaf |
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Institution: | 1. Department of Oral and Maxillofacial Surgery, Sheikh Khalifa General Hospital Umm Al Quwain, (Head: Ahmed Al-Dam, MD, DMD), Al Salama, Opp. Ministry of Social Affairs, Umm Al Quwain, United Arab Emirates;2. Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, (Head: Henning Hanken, MD, DMD, PhD), Martinistr. 52, 20246, Hamburg, Germany;3. Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, (Head: Stefan W. Schneider, MD, DMD), Martinistr. 52, 20246, Hamburg, Germany;4. Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, (Head: Heiko Becher, PhD), Martinistr. 52, 20246, Hamburg, Germany;5. Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, Corporate Member of Free University of Berlin, Humboldt-University of Berlin, and Berlin Institute of Health, (Head: Max Heiland, MD, DMD, PhD), Augustenburger Platz 1, 13353, Berlin, Germany |
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Abstract: | PurposeThe purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.Patients and methodsA sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection. Lymph nodes were examined histologically. The endpoint of this study was to investigate the rate of false-negative results in SLNB.ResultsSentinel lymph nodes could be detected after 8.1 min (range 1–22 min). In eight out of 20 cases, lymph node metastases were found during histopathological evaluation of the neck dissection specimen. In four cases a metastasis could be found in the detected SLN (sensitivity 50%). In the other four cases metastases were found in different lymph nodes. Specificity was 100%, positive predictive value 100%, and negative predictive value 75%.ConclusionIn this study, reliability of sentinel lymph node biopsy after ICG imaging could not be verified, as there were false-negative results in 50% of the cases. Therefore, SND can still be recommended as for patients with cT1 or cT2 OSCC, and a N0 neck status. |
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Keywords: | Sentinel lymph node biopsy Head and neck cancer Oral cancer Lymph node metastases ICG |
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