Axonal transport of actin and regeneration rate in non-myelinated sensory nerve fibres |
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| Authors: | WG McLean |
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| Institution: | 1. Urology Department, Grenoble University Hospital, Grenoble, France;2. TIMC-IMAG UMR CNRS 5525, Domaine de la Merci, La Tronche, France;3. Clinical Investigation Center, Grenoble University Hospital, Grenoble, France;4. Radiology Department, Grenoble University Hospital, Grenoble, France;1. Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;2. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;4. Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;5. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;6. Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan;1. Laboratory of Applied Mechanobiology, Vladimir-Prelog-Weg 4, ETH Zurich, Switzerland;2. SCOPEM – Scientific Center for Optical and Electron Microscopy, ETH Zurich, Switzerland;1. ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St., Paul Lez Durance Cedex, France;2. Institute of Plasma Physics of the CAS, Za Slovankou 3, 182 00 Prague, Czechia;3. AVS, Pol. Ind. Sigma Xixilion Kalea 2, Bajo Pabellón 10, 20870 Elgoibar, Spain;4. NATEC, C/Marqués de San Esteban 52 entlo D, 33206 Gijón, Spain;5. Sogeti High Tech, 180 Rue René Descartes, 13857 Aix-en-Provence, France;6. Intransic Engineering Ltd, Osler Road, Oxford, United Kingdom |
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| Abstract: | The relationship was examined between the rate of regeneration and rate of axonal transport of actin in the sensory fibres of the rabbit vagus nerve. Regeneration rate, determined as the distance moved by 35S]methionine-radiolabelled, fast-transported proteins beyond a crush, was about 3 mm/day. The rate of transport of actin, identified by two-dimensional polyacrylamide gel electrophoresis with fluorography, and DNase affinity chromatography, was 25-30 mm/day. No slower rate of actin transport comparable with regeneration rate, could be found in either control or regenerating nerves. While the provision of actin, by slow axonal transport, to the axonal growth cone may be essential for nerve regeneration, the regeneration rate is not directly controlled by the rate of actin transport. |
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| Keywords: | axonal transport regeneration actin vagus nerve cytoskeleton |
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