滋阴抑抗汤联合地塞米松治疗不孕症临床研究

目的观察滋阴抑抗汤联合地塞米松治疗抗人绒毛膜促性腺激素抗体(HCG-Ab)阳性继发性不孕症患者的临床疗效及对HCG-Ab滴度的影响。方法将60例HCG-Ab阳性的继发性不孕症患者随机分为2组,每组30例。治疗组予滋阴抑抗汤联合地塞米松治疗,对照组予单纯地塞米松治疗。观察治疗前后中医临床症状积分、HCG-Ab滴度变化,并比较2组临床疗效。结果 2组中医症状积分均较治疗前显著降低(P0.01),治疗组优于对照组(P0.01);2组HCG-Ab滴度均较治疗前显著降低(P0.05,P0.01),治疗后2组比较,差异无统计学意义(P0.05);治疗组总有效率为63.33%(19/30),对照组为47.66%(14/30),治疗组优于对照组(P0.05)。结论滋阴抑抗方联合地塞米松能改善HCG-Ab阳性继发性不孕患者的临床症状,促进妊娠。

Clinical Research of Ziyin Yikang Recipe on Anti-HCG Antibody Positive Secondary Sterility

Objective To observe the clinical efficacy of Ziyin Yikang Recipe plus hexadecadrol on anti-HCG antibody positive secondary sterility and the influence on anti-HCG antibody titers. Methods Sixty patients with anti-HCG antibody positive secondary sterility were randomly divided into treatment group （TG） and control group （CG）, 30 cases in each. Patients in the TG were treated with Ziyin Yikang Recipe plus hexadecadrol, while patients in the CG were given hexadecadrol only. The Chinese medicine symptom scores and changes of anti-HCG antibody titers were evaluated and compared between the two groups.Results The Chinese medicine symptom scores in the two groups decreased compared with those before treatment （P〈0.05）, and the TG showed a more significant decrease than the CG （P〈0.05）. The anti-HCG antibody titers in both groups dropped compared with those before treatment （P〈0.05, P〈0.01）. There was no statistically difference between the two group after treatment （P〉0.05）. The total effective rate in the TG was higher that that in the CG （P〈0.05）, with 63.33% （19/30） in the TG and 47.66% （14/30） in the CG.Conclusion The treatment of Ziyin Yikang Recipe plus hexadecadrol on anti-HCG positive secondary sterility can obviously improve the clinical syndrome of yin deficiency and fire hyperactivity, and promote pregnancy success.