Sleeve Gastrectomy Induces Weight Loss in Diet-Induced Obese Rats Even if High-Fat Feeding Is Continued |
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Authors: | V??ctor Valent?? Marina Mart??n Beatriz Ram??rez Javier G??mez-Ambrosi Amaia Rodr??guez Victoria Catal??n Sara Becerril Andoni Lancha Secundino Fern??ndez Javier A Cienfuegos Mar??a A Burrell Gema Fr??hbeck |
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Institution: | 1. Department of Surgery, Cl??nica Universidad de Navarra, Pamplona, Spain 2. Department of Histology and Pathology, University of Navarra, Pamplona, Spain 3. Metabolic Research Laboratory, University of Navarra, Pamplona, Spain 4. CIBER Fisiopatolog??a de la Obesidad y Nutrici??n, Instituto de Salud Carlos III, University of Navarra, Pamplona, Spain 5. Department of Otorhinolaryngology, Cl??nica Universidad de Navarra, Pamplona, Spain 6. Department of Endocrinology and Nutrition, Cl??nica Universidad de Navarra, University of Navarra, Avda. P??o XII, 36, 31008, Pamplona, Spain
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Abstract: | Background Sleeve gastrectomy (SG) has been used for the surgical treatment of morbid obesity as a first or definitive procedure with satisfactory results. The objective of this study in rats was to establish the effects of SG on weight loss depending on the post-surgical type of diet followed. Methods Thirty male Wistar rats were fed ad libitum during 3 months on a high-fat diet (HFD) to induce obesity. After this first phase, rats were subdivided in three groups of ten rats each and underwent a sham intervention, an SG, or no surgery but were pair-fed to the amount of food eaten by the animals of the SG group. At this time point, half of the animals in each group continued to be fed on the HFD, while the other half was switched to a normal chow diet (ND). Thus, the following subgroups were established: sham-ND, sleeve-ND, pair-fed-ND as well as sham-HFD, sleeve-HFD, and pair-fed-HFD. Body weight and food intake were recorded daily for 4 weeks. The feed efficiency rate (FER) was determined from weekly weight gains and caloric consumption during this period. Results Statistically significant (P?<?0.05) differences in body weight were observed between the six experimental groups after 4 weeks of the interventions with rats in the sleeve-ND group experimenting the highest weight loss (?78.2?±?10.3 g) and animals in the pair-fed-HFD group exhibiting the lowest weight reduction (?4.0?±?0.1 g). Interestingly, the FER value of rats that underwent the SG and continued to be fed on a HFD was significantly (P?<?0.05) lower than that of sham operated and pair-fed animals on the same diet. Conclusion The positive effects of SG on weight reduction are observed in obese rats submitted to the intervention and subsequently following an ND or even an HFD. |
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