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| 芒果苷的结构修饰 | |
| 引用本文： | 廖洪利,吴秋业,胡宏岗,臧志和,宋丽,杨倩.芒果苷的结构修饰[J].华西药学杂志,2008,23(4). |
| 作者姓名： | 廖洪利 吴秋业 胡宏岗 臧志和 宋丽 杨倩 |
| 作者单位： | 1. 成都医学院药学院,四川,成都,610083;第二军医大学药学院,上海,200433 2. 第二军医大学药学院,上海,200433 3. 成都医学院药学院,四川,成都,610083 |
| 摘 要： | 目的对芒果苷进行结构修饰,寻求新的抗糖尿病化合物。方法以芒果苷为原料,经烷基化得到一系列3,6,7-O-三取代芒果苷衍生物,并以芒果苷为对照进行体外抗糖尿病活性测试。结果共合成了11个目标化合物,结构均经核磁共振氢谱确证。结论化合物5和11显示出比芒果苷更强的抗糖尿病活性。 |
| 关 键 词： | 芒果苷 结构修饰 抗糖尿病活性 |
Structure modification of mangiferin |
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| LIAO Hong-li,WU Qiu-ye,HU Hong-gang,ZANG Zhi-he,SONG Li,YANG Qian.Structure modification of mangiferin[J].West China Journal of Pharmaceutical Sciences,2008,23(4). | |
| Authors: | LIAO Hong-li WU Qiu-ye HU Hong-gang ZANG Zhi-he SONG Li YANG Qian |
| Abstract: | OBJECTIVE In order to look for new antidiabetic compounds,the structure of mangiferin is modified.METHODS Using mangiferin as starting material,a series of 3,6,7-O-trisubstituted derivatives of mangiferin were synthesized,and then their antidiabetic activities were tested in vitro with mangiferin as the control.RESULTS A total of 11 target compounds were synthesized,and their structures were all confirmed by 1HNMR.CONCLUSION Compounds 5 and 11 were shown to have better antidiabetic activities than mangiferin. |
| Keywords: | mangiferin structure modification antidiabetic activity |
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