| 增生性玻璃体视网膜病变玻璃体切割物的细胞凋亡观察 |
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| 引用本文： | 杨桦,管红兵,张皙.增生性玻璃体视网膜病变玻璃体切割物的细胞凋亡观察[J].中华眼底病杂志,1999,15(2):81-83. |
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| 作者姓名： | 杨桦 管红兵 张皙 |
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| 作者单位： | 上海市第一人民医院眼科 |
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| 摘 要： | 目的观察增生性玻璃体视网膜病变玻璃体切割物的细胞凋亡情况 。方法收集60例不同分级的增生性玻璃体视网膜病变患者的玻璃体切割物，核苷酸末端转移酶介导dUTP缺口翻译法(TdT-mediated dUTP nick end label ling method，TUNEL法)标记凋亡细胞，光镜观察。结果60例患者的玻璃体切割物均有细胞凋亡的特征性改变，随着病变程度的加重，非色素细胞凋亡总数逐渐减少，并出现色素细胞凋亡。结论增生性玻璃体视网膜病变存在不同类型细胞的凋亡，细胞凋亡是调控其病变程度的重要机制之一。(中华眼底病杂志,1999,15:81-83)
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| 关 键 词： | 玻璃体 视网膜病变 增生性 细胞凋亡 |
| 收稿时间： | 1998-11-09 |
| 修稿时间： | 1998-12-28 |
The observation on apoptosis from vitrectomy specimens of proliferative vitreoretinopathy |
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| YANG Hua,GUAN Hongbing,ZHANG Xi,et al..The observation on apoptosis from vitrectomy specimens of proliferative vitreoretinopathy[J].Chinese Journal of Ocular Fundus Diseases,1999,15(2):81-83. |
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| Authors: | YANG Hua GUAN Hongbing ZHANG Xi |
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| Institution: | YANG Hua,GUAN Hongbing,ZHANG Xi,et al.Department of Ophthalmology,Shanghai Eye
Research Institute,Shanghai First Peoples Hospital,Shanghai Medical University,Shanghai
200080,China |
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| Abstract: | urpose To investigate apoptosis in vitrectomy specimens of
proliferative vitreoretinopathy. Methods Vitrectomy specimens from 60 cases of different
classes of proliferative vitreoretinopathy were studied by TdTmediated dUTP nick end
labelling(TUNEL)method. Results The characteristic change of apoptosis was observed in all
vitrectomy specimens.The amount of apoptotic nonpigmentary cell is gradually decreasing
along with the development of proliferative vitreoretinopathy,and apoptotic pigmentary cells are
observed. Conclusion There are different kinds of apoptosis cell in vitrectomy specimens of
proliferative vitreoretinopathy.It is suggested that apoptosis might be one of the important
mechanisms of regulating the degree in proliferative vitreoretinopathy. |
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| Keywords: | Vitreoretinopathy proliferative/pathologyCell death |
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