| 水红花子醇提物的抗脂质过氧化作用 |
| |
| 引用本文： | 张振明,雷晓燕,许爱霞,高湘,葛斌.水红花子醇提物的抗脂质过氧化作用[J].中国药学杂志,2005,40(13):991-992. |
| |
| 作者姓名： | 张振明 雷晓燕 许爱霞 高湘 葛斌 |
| |
| 作者单位： | 1. 甘肃省人民医院药剂科,甘肃,兰州,730000
2. 甘肃省人民医院小儿科,甘肃,兰州,730000 |
| |
| 摘 要： | 目的研究水红花子醇提物的抗脂质过氧化作用。方法用D-半乳糖造衰老小鼠模型,同时ig相当于水红花子0.6,1.2,2.4,4.8g·kg-1·d-1醇提物,观察其对衰老模型小鼠抗氧化系统的影响。结果0.6,1.2,2.4,4.8g·kg-1·d-1水红花子醇提物能使衰老模型小鼠血清、肝、肾组织中MDA明显下降;SOD及CSH-PX活力明显提高;脑组织中LF明显下降。结论水红花子醇提物有显著清除氧自由基,活性氧及抗脂质过氧化作用。
|
| 关 键 词： | 水红花子醇提物 氧自由基 活性氧 脂质过氧化 |
| 文章编号： | 1001-2494(2005)13-0991-03 |
| 收稿时间： | 2004-08-09; |
Effects of alcohol extract from Fructus Polygoni Orientalis on antilipoperoxidation |
| |
| ZHANG Zhen-Ming,LEI Xiao-Yan,XU Ai-xia,GAO Xiang,Ge Bin.Effects of alcohol extract from Fructus Polygoni Orientalis on antilipoperoxidation[J].Chinese Pharmaceutical Journal,2005,40(13):991-992. |
| |
| Authors: | ZHANG Zhen-Ming LEI Xiao-Yan XU Ai-xia GAO Xiang Ge Bin |
| |
| Institution: | 1. Department of Pharmaceutics，People's Hospital of Gansu Province, Lanzhou 730000, China；2. Department of Pediatrics， People′s Hospital of Gansu Province，Lanzhou 730000，China |
| |
| Abstract: | OBJECTIVE To study the effect of the alcohol extract from Fructus Polygoni Orientals (EFPO) on antilipoperoxi-dation.METHODS The effect on antioxidation system in senile model caused by D-galatose (D-gal) was observed.The alcohol extract at a dose of 0.6,1.2, 2.4,4.8 g·kg-1·d-1 was administered,respectively.RESULTS MDA decreased significantly. The activities of SOD and GSH-PX notably ascended in serum,liver and kidney,LF descended in brain of senile model mice. CONCLUSION EFPO possess the notable effect of eliminating oxygen free radicals, active oxygen and antilipoperoxidation. |
| |
| Keywords: | Fructus Polygoni Orientalis oxyen free radicals active oxyen antilipoperoxidation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
| 点击此处可从《中国药学杂志》下载免费的PDF全文 |
|
