寄生虫应激蛋白的研究进展

应激蛋白是细胞或生物体受到各种不同环境因素刺激后产生的一种非特异性蛋白,主要包括急性期反应蛋白、热激蛋白、某些酶或细胞因子等。其中,急性期反应蛋白是一种起动迅速的机体防御机制,属于分泌型蛋白;热激蛋白是细胞受到热应激后新合成的一类遗传上高度保守的蛋白,属于非分泌型蛋白,在应激蛋白中研究最为深入。该文主要阐述了热激蛋白家族的历史和分类,对热激蛋白在寄生虫学领域的研究进展进行了综述。

Progress on study of stress proteins of parasites

Stress proteins are non-specific proteins produced by cells or living bodies after stimulations of various environmental agents, including acute phase protein, heat shock proteins, enzymes and cytokines, etc.. Acute phase proteins, belonging to secreting proteins, increase quickly upon the acute stressors in living organisms. Heat shock proteins, stimulated by heat stress, are highly conserved in heredity that become a hot topic in the research area of stress proteins. This review summarizes the history, classification of heat shock proteins family and the progress on study of heat shock proteins in parasitology research field.