糖尿病对大鼠牙周组织及诱导型一氧化氮合酶分布的影响

目的：观察糖尿病对大鼠牙周炎牙周组织形态结构的影响及诱导型一氧化氮合酶（iNOS）在牙龈组织中的分布。方法：建立大鼠糖尿病牙周炎模型，制作组织切片，进行HE及免疫组织化学染色，观察牙周组织形态结构的破坏情况及iNOS在牙龈组织中的分布。结果：糖尿病牙周炎组的结缔组织附着丧失量及牙槽骨高度丧失量均明显高于牙周炎组、糖尿病组及正常组。差异有显著性（P〈0．05）。糖尿病牙周炎组和糖尿病组的免疫组化染色均为阳性或强阳性。结论：糖尿病加重了牙周炎牙周组织的破坏程度。

Effect of diabetes on periodontal tissue and the distribution of iNOS in periodontitis rats

Objective： To observe the effect of Diabetes on periodontal tissue in periodontitis rats and the distribution of iNOS in gingiva. Methods： After diabetes periodontitis model were established, the tissue sections were stained for histological and immunohistochemistry examination of iNOS to oberserve the damage of periodontal tissue and the distribution of iNOS in gingiva. Results： The loss of the connective tissue attachment and alveolar bone in Diabetes Periodontitis group were significantly higher than other groups （P〈0.05）. the expression of iNOS was positive or strongly positive in Diabetes periodontitis group and Deriodontitis group;The expression was weakly postive in normal group. Conclusion： Diabetes play a role in promoting the damage ofperiodontium.