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Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder |
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| Authors: | Jasmin Roohi Carla J. DeVincent Eli Hatchwell Kenneth D. Gadow |
| Affiliation: | (1) Department of Genetics, Stony Brook University, Stony Brook, NY, USA;(2) Department of Pediatrics, Cody Center for Autism and Developmental Disabilities, State University of New York, Stony Brook, NY, USA;(3) Department of Pathology, State University of New York, Stony Brook, NY, USA;(4) Department of Psychiatry, State University of New York, Stony Brook, NY, USA;(5) Department of Psychiatry and Behavioral Science, Putnam Hall-South Campus, SUNY at Stony Brook, Stony Brook, NY 11794–8790, USA; |
| Abstract: | The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding. |
| Keywords: | Autism Asperger’ s syndrome PDD-NOS Autism spectrum disorder Attention-deficit/hyperactivity disorder Generalized anxiety disorder Monoamine oxidase MAO-A Genetics |
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