Changes in bone marrow hemopoiesis in donor rabbits

Summary It was shown in an experiment on 17 rabbits that animals from which bone marrow had been extracted in amounts of 10–20 ml one time, 2–3 times at intervals of 4–5 months or 7–8 times at intervals of 1–1.5 months were in good condition during the entire experiment and even put on weight. Four animals from which bone marrow was taken in large quantities (25–50 ml 3–4 times at 4–5 months intervals) developed anemia of a hyporegenerative character 12–16 months after the beginning of the experiment, which was followed by a septic conditions with multiple abscesses in the visceral organs. Hence, repeated extractions of large quantities of bone marrow may bring about severe disorders in hemopoietic processes and a reduction in the body resistance.(Presented by Active Member AMN SSSR A. F. Tur) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 60, No. 8, pp. 43–46, August, 1965