| 喉乳头状瘤及其癌变组织中PTEN蛋白表达与DNA含量分析 |
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| 引用本文： | 张再兴,付兴华,薛丽华. 喉乳头状瘤及其癌变组织中PTEN蛋白表达与DNA含量分析[J]. 陕西医学杂志, 2008, 37(2): 174-176 |
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| 作者姓名： | 张再兴 付兴华 薛丽华 |
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| 作者单位： | 1. 河北唐山华北煤炭医学院附属医院耳鼻咽喉科,唐山,063000
2. 河北医科大学附属第二医院耳鼻咽喉科 |
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| 摘 要： | 目的:研究在喉乳头状瘤及其癌变组织中PTEN蛋白表达及DNA含量的变化,探讨喉乳头状瘤癌变的机制。方法:以正常喉黏膜作对照,应用流式细胞测定技术检测20例喉乳头状瘤、15例喉乳头状瘤伴不典型增生及16例喉乳头状瘤恶变组织中PTEN蛋白表达及DNA含量变化。结果:喉乳头状瘤、喉乳头状瘤伴不典型增生及喉乳头状瘤恶变组织中PTEN蛋白表达逐渐降低,DNA含量逐渐升高,经统计学分析,喉乳头状瘤与恶变组织中PTEN蛋白表达与DNA含量差异显著(P<0.05)。结论:PTEN蛋白异常表达及DNA含量变化可能在喉乳头状瘤恶变机制中发挥重要作用。
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| 关 键 词： | 喉肿瘤/病理生理学 流式细胞术/方法 @PTEN蛋白 @DNA含量 |
| 修稿时间： | 2007-06-13 |
The expression of PTEN protein and analysis of DNA content in laryngeal papilloma and its malignant transformation |
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| Zhang Zaixing,Fu Xinghua,Xue Lihua. The expression of PTEN protein and analysis of DNA content in laryngeal papilloma and its malignant transformation[J]. Shaanxi Medical Journal, 2008, 37(2): 174-176 |
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| Authors: | Zhang Zaixing Fu Xinghua Xue Lihua |
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| Affiliation: | Tangshan 063000 |
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| Abstract: | Objective:To investigate the expression of PTEN protein and analyse DNA content in laryngeal papilloma and its malignant transformation.Methods:20 cases of laryngeal papilloma,15 cases of laryngeal papilloma with epithelial dysplasia and 16 cases of laryngeal papilloma with malignant transformation were examined for PTEN protein expression and the changes of DNA content by flow cytometry.Results:From laryngeal papilloma without epithelial dysplasia tissues to laryngeal papilloma with epithelial dysplasia and laryngeal papilloma malignant transformation,the expression of PTEN protein gradually decreased;the DNA content increased.There was a signficant difference in the expression of PTEN protein between laryngeal papilloma and its malignant transformation(P<0.05).Conculsion:PTEN protein abnormally expressed probably plays an important role in the laryngeal papilloma malignant transformation. |
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| Keywords: | Laryngeal neoplasms/physiopathology Flow cytometry/methods @PTEN protein @ DNA content |
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