肾移植前后表皮生长因子含量研究

为了探讨细胞生长调节因子之一的表皮生长因子（ＥＧＦ）在肾脏损害修复中的作用及ＥＧＦ与肾功能及缺血性肾损伤修复之间的关系，观察了１３８例慢性肾功能衰竭（尿毒症期）患者血ＥＧＦ含量和肾移植术前后血和尿中ＥＧＦ含量。结果显示，肾功能衰竭、肾脏损伤期血ＥＧＦ水平极低，移植后肾功能恢复早期，血ＥＧＦ即明显回升。恢复后期，血ＥＧＦ水平稍降，但仍比移植前增高。血ＥＧＦ含量持续不升高者与急性排斥反应和急性肾小管坏死的发生有关。ＥＧＦ的存在，在肾损伤修复时具有重要的作用。检测血清ＥＧＦ含量可作为判断移植肾损伤修复状态的指标之一。

Determination of epidermal growth factor(EGF)before and after kidney transplantation

In order to study the role of epidermal growth factor(EGF)in the repair of injured renal tissue and the relationship between EGF and the renal function or renal tissue after ischemia damage,the serum EGF(sEGF)level and urinary EGF(uEGF)level in 138 patients with chronic reanl failure(uremia stage)were determined before and after kidney transplantation.The results showed that the sEGF level in the period of chronic renal failure(CRF)and renal tissue damage was extremely low.In the early state of renal function recovery after transplantation,the uEGF level was obviously increased.In the post stage the uEGF level was slightly decreased,but was higher than before transplantation.The uncontinuous increase of uEGF level was related tO occurrence of the acute rejection or acute renal tubular necrosis.It was suggested that EGF might play an important role in the repair of injured renal tissue.The sEGF can be served as an indicator for the evaluation of the repair of transplanted renal damage.