川芎嗪对犬肾保存的影响

通过犬自体肾移植模型研究了一定浓度的川芎嗪加入ＷＭＯ－１号液对犬肾保存效果的影响。结果表明，单纯ＷＭＯ－１号液保存７２小时和加川芎嗪保存７２小时的肾行自体移植均难存活；加川芎嗪保存４８小时组术后血肌酐的平均值低于单纯ＷＭＯ－１号液保存４８小时组，且血肌酐恢复正常的时间也较单纯ＷＭＯ－１号液组早（Ｐ＜０．０５），说明该实验浓度的川芎嗪不能延长肾保存时间，但有利于移植肾功能的早期恢复。

Effect of ligustrazine on canine kidney preservation

The canine kidney autologous transplant model was used to investigate the effect of ligustrazine with a certain concentration added to WMO-1 solution on kidney preservation. The results showed that the canine autologously transplanted kidneys were difficult to survive with 72h preservation of WMO-1 alone and WMO-1 plus ligustrazine. The mean serum creatine level after operation in 48 h ligustrazine preservation group was lower than in 48 h WMO-1 preservation group, and the recovery of serum creatine level in the former group was earlier than in the latter group (P＜0.05). These results suggested that the ligustrazine concentration used could not prolong the preservation time of WMO-1 solution to kidney, but could be of benefit to the recovery of renal function in the early stage.