肾移植患者骨矿含量的测定及临床意义

测量了６４例肾移植患者移植前后的骨矿含量及骨钙素（ＢＧＰ）、甲状旁腺激素（ＰＴＨ）、血液生化的变化，以探讨它们的相互关系及临床意义。结果术前血肌酐（ＳＣｒ）、尿素氮（ＢＵＮ）、磷（Ｐ）、ＰＴＨ、ＢＧＰ为高水平，血钙（Ｃａ）低，骨矿含量（０．７７７±０．０１５ｇ／ｃｍ２）明显低于对照组（０．８１１±０．０３５ｇ／ｃｍ２）。术后肾功能正常者，ＳＣｒ、ＢＵＮ、Ｃａ、Ｐ及ＰＴＨ、ＢＧＰ均恢复正常，骨矿含量半年后恢复至对照组水平。提示慢性肾功能衰竭及血液透析期间存在明显钙磷代谢异常，严重骨营养不良；肾移植成功后骨矿含量恢复，纠正了肾性骨病；肾移植后骨矿含量低者，往往提示预后不良。

Determination of bone minerals in renal transplantation recipients and its clinical implication

The changes in levels of BMD, BGP, PTH, SCr, BUN, Ca2+, P3- were detected in 64 renal transplantation recipients to investigate their interactions and clinical implication.The results showed that serum SCr,BUN,PTH,BGP and P3- were in high level,and the levels of serum Ca2+ and BMD were obviously lower chan those of control group before renal transplantation.After renal trans.plantation,SCr,BUN,Ca,P,PTH and BGP returned to normal levels,and BMD to the level of control group 6 months postoperation.It was suggested that the patients with chronic renal failure within the period of hemodialysis existed obviously metabolic disorder of Ca 2+ and P3+,serious bony malnutrition.BMD might return to normal level after successful renal transplantation.