HLA不全相合骨髓移植治疗白血病五例 |
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引用本文: | 李夏新,黄志光,张肇和,程少杰,钱新华,李春富,武大林,邢献志,陈仲梅,刘纯霞,庄晓青,陈永清,许志新,崔玉明. HLA不全相合骨髓移植治疗白血病五例[J]. 中华器官移植杂志, 1998, 19(3): 180-182 |
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作者姓名: | 李夏新 黄志光 张肇和 程少杰 钱新华 李春富 武大林 邢献志 陈仲梅 刘纯霞 庄晓青 陈永清 许志新 崔玉明 |
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作者单位: | 第一军医大学附属南方医院,广州,510515 |
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基金项目: | 军队“七五”攻关资助项目 |
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摘 要: | 为探讨应用亲属中HLA不全相合供体骨髓移植治疗白血病的疗效,选择性应用HLA1~2个位点不合的血缘供体骨髓移植治疗白血病5例,并长期随访观察其远期疗效。结果5例患者中有3例无病存活1340、1160和900天以上,恢复了正常的生活、工作和学习,1例慢性髓性白血病患者无病存活3年,于嵌合造血状态下复发,正在供体淋巴细胞输注治疗中,1例表兄弟间2个位点不合移植患者因Ⅳ度移植物抗宿主病和配型不合综合征致死。认为HLA不全相合的亲属供体骨髓移植治疗白血病是有应用前景的,然而对移植物抗宿主病的发生应予以足够的重视。
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关 键 词: | 人白细胞抗原 骨髓移植 白血病 移植物抗宿主病 |
HLA mismatched bone marrow transplantation as an alternative treatment for leukemia: a report of 5 cases |
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Abstract: | In order to investigate the feasibility of HLA mismatched family marrow donor for treating the patients with leukemia, HLA one or two locus mismatched family marrow donor was used to treat 5 patients with leukemia and the long-term therapeutic effects were followed up in out-patients for 3 to 4 years. Three patients survived without diseases and with 100% of karnofy score more than 1 340, 1 160 and 900 days after transplant, respectively. One CML patient survived without disease over 3 years, now with hematological relapse in a situation of chimerism,and received donor lymphocyte infusion. One patient transplanted with HLA 2 locus mismatched cousin died of Ⅳ grade GVHD. One to two locus mismatched marrow donor is a good alternative one for treating leukemia patients of non-matched donor, but we should pay enough attention to the earlier occurrence of GVHD for this kind of transplant. |
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Keywords: | HLA antigens Bone marrow/transplantation Leukemia Graft vs host disease |
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