游离PSA和复合PSA在前列腺癌诊断中的应用

目的评估三种形式的前列腺特异性抗原:总前列腺特异性抗原(tPSA)、游离前列腺特异性抗原(fPSA)、复合前列腺特异性抗原(cPSA)及其比值在前列腺癌诊断中的应用。方法150名研究对象分为三组:正常对照组50人,前列腺增生(BPH)组50人,前列腺癌(PCa)组50人。用全自动化学发光免疫法分别测定他们的tPSA、fPSA和cPSA,并计算其比值。结果Pca组的cPSA／tPSA、fPSA／tPSA和fPSA／cPSA比值的均值与BPH组有显著差异(分别为91.0％／68.0％,12.1％／26.3％和13.3％／38.8％,P<0.001),fPSA／cPSA与fPSA／tPSA比值密切相关(r=0.8820)。结论与tPSA相比,cPSA／tPSA、fPSA／tPSA和fPSA／cPSA都可增强其对BPH和PCa的鉴别诊断作用。

Free PSA and Complexed PSA in Diagnosis of Prostate Cancer

Objective To evaluate three forms of prostate-spcific antigen (PSA):total PSA (tPSA),free PSA (fPSA) and complexed PSA (cPSA), and corresponding ratios to improve the differentiation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Methods Serum samples were collected from 50 men without prostate disease,50 untreated patients with PCa,and 50 patients with BPH. tPSA,fPSA and cPSA were measured by an automated chemillumi-nescent immunoassay. Results The median cPSA/tPSA, fPSA/tPSA, and fPSA/cPSA ratios were significantly different between patients with BPH and PCa (68.0% vs 91. 0%,26. 3% vs 12.1%,and 38.8% vs13. 3% ,respectively ;P<0. 001). The fPSA/tPSA ratio was similar to the fPSA/cPSA ratio (r=0. 882 0). Conclusion Compared with tPSA,cPSA/tPSA, fPSA/tPSA,and fPSA/cPSA ratios all improve the differentiation between BPH and PCa comparably.