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| 不同预适应方法抗缺血/再灌注心律失常的实验研究 | |
| 引用本文： | 孙可青,杨少勇,徐长庆,许宏远,李全凤,娄延平.不同预适应方法抗缺血/再灌注心律失常的实验研究[J].中国急救医学,2000,20(5):263-264. |
| 作者姓名： | 孙可青 杨少勇 徐长庆 许宏远 李全凤 娄延平 |
| 作者单位： | 1. 黑龙江省医院内科,150001 2. 哈尔滨医科大学病理生理教研室 3. 黑龙江省电力医院 |
| 摘 要： | 观察不同预适应方法对缺血 /再灌性心律失常的保护作用。方法 采用大鼠离体心脏Langendorff灌流模型 ,用冠脉结扎和松脱来复制心肌缺血再灌注损伤。结果 按Curtis -Walker心律失常评分系统计算 ,缺血再灌注损伤组为3 43± 0 48,药物、结扎和旷置预适应保护组分别降至 1 0 0± 0 45、0 6 7± 0 2 1、0 71± 0 2 9(P <0 0 1)。旷置预适应可使再灌注时的冠脉流出液的乳酸脱氢酶释放量明显减少 (P <0 0 5 ) ,心室纤颤阈显著提高 (P <0 0 5 )。结论 不同预适应方法均具有明显的心肌保护作用 |
| 关 键 词： | 心律失常 大鼠 心肌缺血 缺血预适应 |
Experiment research about the protective effect of different preconditioning methods on ischemia/reperfusion arrhythmias |
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| SUN Ke-qing ,YANG Shao-yong,XU Chang-qing,et al Heilongjiang Province Hospital,Harbin ,China.Experiment research about the protective effect of different preconditioning methods on ischemia/reperfusion arrhythmias[J].Chinese Journal of Critical Care Medicine,2000,20(5):263-264. | |
| Authors: | SUN Ke-qing YANG Shao-yong XU Chang-qing Heilongjiang Province Hospital Harbin China [ |
| Institution: | SUN Ke-qing 1,YANG Shao-yong,XU Chang-qing,et al 1Heilongjiang Province Hospital,Harbin 150001,China [ |
| Abstract: | Objective To observe the protective effect of different preconditioning (PC) methods on ischemia/reperfusion arrhythmia Methods A model of reperfusion after 10 mins of the left descending coronary artery occlusion in langendorff rat hearts was used Results Tree preconditioning methods (ISO,occlusion, no perfusion) markedly decreased the severity of arrhythmias( P <0 01) While the PC by zero-flow global ischemia deceased the amount of LDH in effluxion of the coronary artery and increased VFT during reperfusion Conclusion The different PC can protect heart from ischemia/reperfusion induced arrythmias |
| Keywords: | Preconditioning Ischimia/reperfusion Arrthymia Ventricular fibrillation threshold Rat |
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