血液透析对血浆内皮素和一氧化氮水平的影响

目的：了解不同血液透析方式对血浆内皮素（ET）和一氧化氮（NO）水平的影响，以及内皮素和一氧化氮对透析过程中低血压发生的作用。方法：分别对30例普通透析（HD）患者、20例血液滤过透析（HDF）患者透析前后以及22例HD患者透析过程中发生低血压时和血压正常时血浆NO和ET－1水平进行测定、比较。结果：HD、HDF透析后血浆ET－1水平升高（P＜0．05），血浆NO水平降低（P＜0．05），这种变化以HDF为著。HD过程中发生低血压时血浆NO浓度降低、ET－1升高，与血压正常时差异有显著性意义（P＜0．05）。结论：不同血液透析方式影响血浆ET－1与NO水平，HDF影响较HD大。透析过程中发生低血压后血浆ET－1升高、NO降低。

Effect of hemodialysis on plasma level endothelin and nitric oxide

Objective:To study the effect of different kinds of hemodialysis on plasma endothelin and nitric oxide concentration in the course of hemodialysis.Methods:The plasma ET and NO were measured and compared before and after HD,HDF,and they were compared between low blood pressure and normal blood pressure in the course of hemodialysis.Results:The plasma ET level of HD and HDF increased after HD(P<0.05),the plasma NO level decreased(P<0.05),with the remarkable change of HDF.The plasma NO concentration was lower,ET-1 became higher,when low blood pressure occured in the course of hemodialysis,which was significantly different from that of normal blood pressure(P<0.05).Conclusion:Hemodialysis produces an effect on the plasma level of ET and NO,more remarkably on HDF than on HD. Plasma ET-1 increase and NO decrease when low blood pressure occures in the course of hemodialysis,which is possibly a phenomenon of physical compensation.