EB病毒和人乳头状瘤病毒感染与鼻、鼻窦内翻性乳头状瘤的关系

探讨鼻、鼻窦内翻性乳头状瘤中人乳头状瘤病毒和ＥＢ病毒的感染率及临床意义。方法：用聚合酶链反应方法检测３０例有随机记录的鼻、鼻窦内翻性乳头状瘤及恶变的石蜡包埋组织标本中的人乳头状瘤病毒和ＥＢ病毒基因。结果：３０例中检出ＨＰＶ２０例（６６．７％），ＥＢ病毒１２例（４０％），其中９例乳头状瘤恶变组织中检出ＨＰＶ单独感染４例（全部为ＨＰＶ１６型），ＥＢ病毒单独感染４例。两者混合感染１例，即９例乳头状瘤恶变

RELATIONSHIP BETWEEN SINONASAL INVERTED PAPILLOMA AND INFECTION OF EPSTEIN - BARR VIRUS AND HUMAN PAPILLOMAVIRUS Gao

Objective: To investigate the infection of Epstain - Barr virus (EBV) and human papillomavirus (HPV) in sinonasal inverted papilloma and its clinical significance. Method: EBV and HPV DNA were detected in paraffin -embedded tissues of 30 cases of sinonasal inverted papillomas and papilloma with malignant transformation by polymeras chain reaction. All of thes patients had complete following -up data. Result: EBV and HPV were found respectively in 12(40%) and 20(66. 7%) of the 30 cases. Among 9 papilloma cases with malignant transformation, EBV was positive in 4 ones. HPV was also positive in 4 ones, the other one was mixed infection of these two viruses. That is to say. tumor virus infected all of these 9 cases. But 10 nasal polyes contained neither HPV nor EBV. It was found that EBV infection had a relationship with the recurrence of inverted papilloma. Conclusion: Infection of HPV as well as EBV has a relationship with sinonasal inverted papillomas, HPV16 is related to malignant transformation and EBV is related to recurrence of sinonasal inverted papillomas.