Pulmonary alveolar proteinosis: Determination of prostaglandins and leukotrienes in lavage fluid |
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| Authors: | Frederik J. Zijlstra J. Eric Vincent Bart van den Berg Henk C. Hoogsteden Herman J. Neyens Jacques J. M. van Dongen |
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| Affiliation: | (1) Department of Pulmonary Medicine, Erasmus University and Academic Hospital Dijkzigt, Rotterdam, The Netherlands;(2) Departments of Pediatrics, Erasmus University and Academic Hospital Dijkzigt, Rotterdam, The Netherlands;(3) Departments of Cell Biology, Erasmus University and Academic Hospital Dijkzigt, Rotterdam, The Netherlands;(4) Department of Pharmacology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands |
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| Abstract: | In bronchoalveolar lavage fluid from a patient with pulmonary alveolar proteinosis, leukotrienes and prostaglandins were measured on 4 occasions during 10 months. Large amounts of leukotriene-C4-like substances (10–25 nmol) and oxygenated products of leukotriene B4 were detected. These substances were characterized by the measurement of absorption spectra in high-performance liquid chromatography, biological activities by means of guinea pig lung parenchymal strips, and immunoreactivities in radioimmunoassay. The cyclooxygenase products of arachidonic acid were present in lower amounts (40–500 pmol). Our results indicate that arachidonic acid metabolites are mainly present in the first fraction of the lavage fluid. These substances may have been formed by alveolar macrophages. |
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| Keywords: | Leukotrienes Prostaglandins Pulmonary alveolar proteinosis Lavage fluid |
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