| 冀、京、吉犬群犬腺病毒中和抗体调查 |
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| 引用本文： | 钱方,张守峰,王述超,刘晔,赵敬慧,米立娟,张菲,王颖,扈荣良.冀、京、吉犬群犬腺病毒中和抗体调查[J].中国人兽共患病杂志,2014(2):155-157. |
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| 作者姓名： | 钱方 张守峰 王述超 刘晔 赵敬慧 米立娟 张菲 王颖 扈荣良 |
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| 作者单位： | 军事医学科学院军事兽医研究所、吉林省人兽共患病预防与控制重点实验室,长春130122 |
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| 基金项目： | 国家高技术研究发展计划（No.2011AAl0A212）资助 |
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| 摘 要： | 目的为表达狂犬病病毒糖蛋白的犬2型腺病毒（CAV-2）重组狂犬病口服疫苗的投放工作提供流行病学依据。方法通过病毒中和试验对随机采自河北省，北京市，吉林省等地的387份犬血清进行犬腺病毒中和抗体检测，以确定犬群腺病毒感染率。结果河北、吉林农村流浪犬或家养犬腺病毒中和抗体阳性率较低，阳性率为16％（30／192），而北京市犬腺病毒中和抗体阳性率高达69％（135／195），说明城乡犬只犬腺病毒中和抗体存在明显差异。结论农村流浪犬或家养犬腺病毒中和抗体阳性率较低，适用于CAV-2及其重组疫苗首次免疫、尤其是口服免疫。
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| 关 键 词： | 狂犬病 犬腺病毒 中和抗体 口服免疫 |
Neutralizing antibody against canine adenovirus in dogs |
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| QIAN Fang,ZHANG Shou-feng,WANG Shu-chao,LIU Ye,ZHAO Jing-hui,MI Li-juan,ZHANG Fei,WANG Ying,HU Rong-liang.Neutralizing antibody against canine adenovirus in dogs[J].Chinese Journal of Zoonoses,2014(2):155-157. |
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| Authors: | QIAN Fang ZHANG Shou-feng WANG Shu-chao LIU Ye ZHAO Jing-hui MI Li-juan ZHANG Fei WANG Ying HU Rong-liang |
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| Institution: | (Institute of Military Veterinary, Military Academy of Medical SciencesKey Laboratory of J ilin Province for Zoonosis Prevention and Control, Changchun 130122, China) |
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| Abstract: | In order to obtain the prevalence data of canine adenovirus （CAV） in China for providing references for the CAV-2 vectored rabies vaccine application, neutralizing antibody assay was performed to determine the antibody titer against canine adenovirus of 387 serum samples randomly collected from Hebei, Beijing and Jilin provinces. Significant difference of the CAV antibody positive rates was found between the rural and urban areas 16% （30/192） and 69% （135/195）, respectively]. Therefore, the recombinant CAV-2 expressing rabies virus glycoprotein could be an adequate oral vaccine candidate in some rural areas of China. |
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| Keywords: | rabies canine adenovirus neutralizing antibody oral immunization |
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