ER、PR及C-erbB-2表达与乳腺癌临床病理特征及其预后的关系 |
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引用本文: | 张晟,刘鹏,只向成,孟洁,张敏,李春艳,张瑾.ER、PR及C-erbB-2表达与乳腺癌临床病理特征及其预后的关系[J].实用癌症杂志,2009,24(5):447-449. |
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作者姓名: | 张晟 刘鹏 只向成 孟洁 张敏 李春艳 张瑾 |
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作者单位: | 教育部乳腺癌防治重点实验室,天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院,300060 |
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基金项目: | 300060天津医科大学附属肿瘤医院,教育部乳腺癌防治重点实验室,天津市肿瘤防治重点实验室 |
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摘 要: | 目的探讨ER、PR、C—erbB-2表达与乳腺癌临床病理特征及其预后的关系。方法采用免疫组化方法,对1568例乳腺癌患者进行ER、PR、C—erbB-2检测,并分析其与患者年龄、家族史、肿瘤体积、淋巴结转移数目、病理类型、组织学分级及预后患者的关系。结果C—erbB-2表达阳性组患者具有年龄较小(P=0.001)、肿瘤体积较大(P=0.001)、组织学分级较差(P=0.002)、淋巴结转移数目较多(P:0.001)、预后较差(P:0.001)等特点;ER,PR,C—erbB-2表达均阴性的患者预后也较差。结论激素受体及C—erbB-2表达水平可作为制定乳腺癌治疗方案的重要参考指标。
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关 键 词: | 乳腺癌 雌激素受体 孕激素受体 C—erbB-2基因 |
The Relationship between the Expression of ER, PR, C-erB-2 and the Clinical and Pathological Characteristic in Breast Cancer |
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Abstract: | Objective To explore the relationship between the expression of ER, PR, C - erbB - 2 and the clinical and pathological characteristics in female patients with breast cancer. Methods The expression of ER, PR, C - erbB - 2 was detected by using immunohistochemical method. The relationship between the expression of ER, PR, C - erbB -2 and the age, family history, tumor size, metastatie node numbers, pathological type, histological grade and prognosis was evaluated. Results The patients with positive C -erbB -2 expression were significantly correlated to younger age (P = 0.00l ) ,larger tumor size (P = 0. 001 ) , poorer histological grade ( P= 0. 002 ) , more metastatic node numbers ( P= 0. 001 ) and poorer prognosis ( P = 0. 001 ). Patients with combined negative expression of ER, PR and C - erbB - 2 also had poorer prognosis. Conclusion Different hormonal receptor and HER-2 status indicate different clinical and pathological characteristic, it would be the important reference when the treatment plan was made. |
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Keywords: | Breast cancer Estrogen receptor: Progesterone receptor: C-erbB-2 gene |
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