| Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray |
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| 引用本文： | Lei Xu,You-Ming Li,Chao-Hui Yu,Lan Li,You-Shi Liu,Bao-Feng Zhang,Jing Fang,Qiong Zhou,Ying Hu and Hen-Jun Gao Department of Gastroenterology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China and National Engineering Center for Biochip,Shanghai 200000,China. Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray[J]. Hepatobiliary & Pancreatic Diseases International, 2006, 0(1) |
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| 作者姓名： | Lei Xu You-Ming Li Chao-Hui Yu Lan Li You-Shi Liu Bao-Feng Zhang Jing Fang Qiong Zhou Ying Hu and Hen-Jun Gao Department of Gastroenterology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China and National Engineering Center for Biochip Shanghai 200000 China |
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| 作者单位： | Lei Xu，You-Ming Li，Chao-Hui Yu，Lan Li，You-Shi Liu，Bao-Feng Zhang，Jing Fang，Qiong Zhou，Ying Hu and Hen-Jun Gao Department of Gastroenterology，First Affiliated Hospital，Zhejiang University School of Medicine，Hangzhou 310003，China and National Engineering Center for Biochip，Shanghai 200000，China |
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| 基金项目： | The study was supported by a grant from the National 863 program (2002AA2Z2021). |
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| 摘 要： | BACKGROUND: Pancreatic cancer development and progression is driven by the accumulation of genetic changes. In this study we constructed tissue microarray containing specimens from pancreatic cancer, adjacent non-cancer tissue and normal tissue to survey the expression of p53, p16 and cyclooxyganase-2 (COX-2). METHODS: Tissue microarray containing 337 specimens from different stages of pancreatic cancer, adjacent noncancer tissue and normal tissues was constructed, and the expression of p53, p16 and COX-2 was assayed by immunohistochemistry to consecutive formalin-fixed tissue microarray sections. RESULTS: The expression of p53, p16 and COX-2 was significantly higher in tumorous tissues than in non-tumorons ones. A significant relationship was observed between p53 and COX-2, or p16 and COX-2. But no obvious correlation was seen between p53 and p16 expressions. Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. CONCLUSION: Combination analysis of p53 and COX-2 may be useful in predicting pancreatic carcinogenesis.
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Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray |
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| Lei Xu,You-Ming Li,Chao-Hui Yu,Lan Li,You-Shi Liu,Bao-Feng Zhang,Jing Fang,Qiong Zhou,Ying Hu and Hen-Jun Gao. Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray[J]. 国际肝胆胰疾病杂志, 2006, 0(1) |
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| Authors: | Lei Xu You-Ming Li Chao-Hui Yu Lan Li You-Shi Liu Bao-Feng Zhang Jing Fang Qiong Zhou Ying Hu Hen-Jun Gao |
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| Affiliation: | Lei Xu,You-Ming Li,Chao-Hui Yu,Lan Li,You-Shi Liu,Bao-Feng Zhang,Jing Fang,Qiong Zhou,Ying Hu and Hen-Jun Gao Department of Gastroenterology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China and National Engineering Center for Biochip,Shanghai 200000,China |
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| Abstract: | BACKGROUND: Pancreatic cancer development and progression is driven by the accumulation of genetic changes. In this study we constructed tissue microarray containing specimens from pancreatic cancer, adjacent non-cancer tissue and normal tissue to survey the expression of p53, p16 and cyclooxyganase-2 (COX-2). METHODS: Tissue microarray containing 337 specimens from different stages of pancreatic cancer, adjacent noncancer tissue and normal tissues was constructed, and the expression of p53, p16 and COX-2 was assayed by immunohistochemistry to consecutive formalin-fixed tissue microarray sections. RESULTS: The expression of p53, p16 and COX-2 was significantly higher in tumorous tissues than in non-tumorons ones. A significant relationship was observed between p53 and COX-2, or p16 and COX-2. But no obvious correlation was seen between p53 and p16 expressions. Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. CONCLUSION: Combination analysis of p53 and COX-2 may be useful in predicting pancreatic carcinogenesis. |
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| Keywords: | pancreatic cancer tissue microarray p53 p16 cyclooxygenase-2 |
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