Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury |
| |
Authors: | Aydin Adem Genç Kursad Akhisaroglu Mustafa Yorukoglu Kutsal Gokmen Necati Gonullu Erdem |
| |
Affiliation: | Department of Pediatric Neurology, School of Medicine, University of Dokuz Eylül, Izmir, Turkey. adem.aydin@deu.edu.tr |
| |
Abstract: | Hypoxic-ischemic encephalopathy seen in survivors of perinatal asphyxia is a frequently encountered and a major clinical problem for which there is currently no effective treatment. Hematopoietic neuroprotective agents, such as erythropoietin (EPO) may rescue neurons from cell death in this setting. EPO is a cytokine hormone that has neuroprotective effect in vitro and in vivo. In this study, we evaluated the effect of posthypoxic EPO administration in an animal model of neonatal hypoxic-ischemic injury. Our results show that a single intracerebroventricular injection of EPO immediately after hypoxic-ischemic insult in neonatal rat model of hypoxic-ischemia reduced the extent of hypoxic-ischemic brain damage. The mean infarct volume assessed 7 days after hypoxia was significantly smaller in EPO-treated group than in the control group. These findings suggest that EPO may provide benefit after hypoxic-ischemic events in the developing brain, a major contributor to static encephalopathy and cerebral palsy. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|