Intracisternal injection of TRH antibody blocks gastric emptying stimulated by 2-deoxy-d-glucose in rats |
| |
| Authors: | Toshikatsu Okumura,Ian L. Taylor,Gordon Ohning,Yvette Taché ,Theodore N. Pappas |
| |
| Affiliation: | aDepartment of Surgery, PO Box 3479, Duke University Medical Center and Veterans Administration Medical Center, Durham, NC 27710,USA;bDepartment of Medicine, Medical University of South Carolina, SC 29425,USA;cCURE Gastroenteric Biology Center, Veterans Affairs Wadworth Medical Center and Department of Medicine and Brain Research Institute, UCLA, Los Angeles, CA 90073,USA |
| |
| Abstract: | We evaluated the effect of 2-deoxy-d-glucose (2-DG) on gastric emptying of a non nutrient solution in conscious rats using a Phenol red method. Intravenous injection of 2-deoxy-d-glucose dose-dependently increased the rate of gastric emptying. This stimulatory action of 2-DG was abolished by subdiaphragmatic vagotomy. Intracisternal injection of thyrotropin-releasing hormone (TRH) antibody blocked intracisternal TRH and intravenous 2-DG-induced enhancement of gastric empyting but not the stimulation of gastric emptying induced by intracisternal pancreatic polypeptide. The TRH antibody injected intraperitoneally had no effect. These results suggest that endogenous TRH in the brain is involved in vagal-dependent stimulation of gastric emptying by 2-DG. |
| |
| Keywords: | 2-Deoxy- font-variant: small-caps" >d-glucose Central nervous system Gastric emptying Thyrotropin-releasing hormone (TRH), Vagotomy Pancreatic polypeptide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
