自体全厚皮片内前列腺素E2含量变化对黑色素细胞密度的影响

目的：测定自体全厚皮片内前列腺素E2含量的动态变化，并观察其含量变化对黑色素细胞（MC）增殖的可能影响。方法：借助放射免疫分析法测定皮片PGE2含量，同时观察表皮内两种MC密度的动态变化。结果：术后7d以前，PGE2含量明显升高，而同期的MC密度经历了减少——缓慢增加这样一个损伤——修复过程。术后1月时，PGE2再次升高不伴MC密度的相应升高，但MC对^3H-TdR的摄取明显升高，表明其处于较强的复制状态。结论：我们有理由相信，PGE2含量的升高对于MC密度的恢复乃至超过术前水平所产生的作用是非常重要的。进一步研究PGE2的功能，并从控制皮片内的PGE2含量入手控制MC增殖，进而控制皮片的色泽，将是大有希望的途径之一。

The Effect of Concentration of Prostaglandin E2 on Density of Melanocytes in the Skin Autografts

Objective:To dete r mine changes in concentration of prostag landin E 2 and to observe the effect of its concentration changes on proliferati on and density of melanocytes in the ski n autografts.Methods:The co ncentration of PGE 2 was determined by u sing radioimmune analysis.The density ch anges of two kinds of melanocytes were e stimated at the same time.Results :PGE 2 concentration in the grafts increased evidently in two days after s urgery,then increased slowly,which was a wound repair process.One month after su rgery,PGE 2 concentration increased agai n without MC density raising,but with an increase of take in of 3 H TdR by MC,w h ich revealed that proliferation of MC wa s strengthened.Conclusion:T here were reasons for us to believe that high concentration of PGE 2 is importan t for returning to and exceeding the nor mal density of MC.Profound study on the function of PGE 2 is necessary.It might be one way to control concentration of P GE 2,then to control proliferation of MC and to adjust the match of skin grafts.