| 胆管癌组织中存活素及MMP-9的表达相关性及临床意义 |
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| 引用本文： | 杜骁,薛冰川,安鑫,许桂祥. 胆管癌组织中存活素及MMP-9的表达相关性及临床意义[J]. 中国现代医生, 2010, 48(7): 1-2,18,F0003 |
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| 作者姓名： | 杜骁 薛冰川 安鑫 许桂祥 |
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| 作者单位： | 1. 山西医科大学第一临床医学院普外科,山西太原,030001
2. 山西医科大学第三医院普外科,山西太原,030053 |
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| 摘 要： | 目的研究存活素及MMP-9在胆管癌组织中的表达情况及其相关性,了解胆管癌组织中存活素及MMP-9表达的相关性及其与胆管癌浸润转移的关系,并讨论其临床意义。方法采用免疫组织化学法(PV-9000)检测45例胆管癌组织中(34例浸润转移组,11例无浸润转移组)存活素和MMP-9的表达情况。结果有浸润转移的34例胆管癌标本中,存活素和MMP-9表达的阳性率分别为61.8%(21/34)和70.6%(24/34);无浸润转移的11例胆管癌标本中,存活素和MMP-9表达的阳性率分别为27.3%(3/11),和36.4%(4/11);存活素的表达与胆管癌浸润转移倾向呈正相关性(P0.05),MMP-9的表达与胆管癌及浸润转移倾向也呈正相关性(P0.01)。存活素与MMP-9的表达呈正相关性(P0.01)。结论存活素及MMP-9在胆管癌组织中的表达呈正相关性,并且二者与胆管癌浸润转移也均呈正相关性,它们可能共同参与了胆管癌的恶变与转移过程。对存活素和MMP-9的联合检测可能作为胆管癌诊断、预后及转移潜能判断的指标。
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| 关 键 词： | 胆管癌 存活素 MMP-9 浸润 转移 免疫组织化学 |
Survivin and Matrix Metalloproteinase 9 in Cholangiocarcinoma:Expression Correlation and Clinical Significance |
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| DU Xiao,XUE Bingchuan,AN Xin,XU Guixiang. Survivin and Matrix Metalloproteinase 9 in Cholangiocarcinoma:Expression Correlation and Clinical Significance[J]. , 2010, 48(7): 1-2,18,F0003 |
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| Authors: | DU Xiao XUE Bingchuan AN Xin XU Guixiang |
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| Affiliation: | DU Xiao1 XUE Bingchuan2 AN Xin2 XU Guixiang1 1.Department of General Surgery,the First Clinical College of Shanxi Medical University,Taiyuan 030001,China,2.Department of General Surgery,the Third Clinical College of Shanxi Medical University,Taiyuan 030053 |
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| Abstract: | Objective To investigate the expression and correlation of survivin and matrix metalloproteinase 9(MMP-9) in cholangiocarci-noma,and evaluate their correlation with invasion and metastasis in cholangiocarcinoma. Methods The expression of survivin and MMP-9 was detected by immunohistochemistry(PV-9000) in 34 cases of cholangiocarcinoma with invasion and metastasis and 11 cases without invasion and metastasis. Results In invasion and metastasis cases,the positive rates of survivin and MMP-9 were 61.8%(21/34)a... |
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| Keywords: | MMP-9 |
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