| 维生素D和维生素K对大鼠结石模型尿晶体成分的影响 |
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| 引用本文： | 连胜,冯陶,郭应禄. 维生素D和维生素K对大鼠结石模型尿晶体成分的影响[J]. 中华实验外科杂志, 1999, 16(3): 240-241 |
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| 作者姓名： | 连胜 冯陶 郭应禄 |
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| 作者单位： | 北京医科大学第一医院泌尿外科研究所!100034 |
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| 基金项目： | 国家自然科学基金!39670722 |
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| 摘 要： | 目的进一步明确维生素D和维生素K与肾结石的关系，探讨成石机制。方法将健康成年雄性SD大鼠24只随机分成4组，即对照组、诱石组、维生素D组和维生素K组，收集第1、3、7天约24小时尿，测定尿晶体成分的浓度。结果维生素D组尿钙和草酸明显高于对照组和诱石组，尿镁和柠檬酸显著降低（P＜0．05）。维生素K组尿草酸明显低于诱石组（P＜0．05）。结论维生素D可能通过多种机制促进肾结石形成，而维生素K有抑制结石形成的作用。
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| 关 键 词： | 肾结石 维生素D 维生素K 动物模型 |
Effects of Vitamin D_3 and vitamin K on urine crystal components of rat stone model |
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| CHANG Lian sheng, FENG Tao, GUO Yinglu. Effects of Vitamin D_3 and vitamin K on urine crystal components of rat stone model[J]. Chinese Journal of Experimental Surgery, 1999, 16(3): 240-241 |
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| Authors: | CHANG Lian sheng FENG Tao GUO Yinglu |
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| Abstract: | Objective To investigate the relationship between kidney calculi and Vitamin D3 aswell as Vitamin K. Methods Twenty-four adult male SD rats were randomly divided into 4 groups(control group, stone-inducing group, Vitamin D3 group and Vitamin K group). The urine were collected at day 1, 3 and 7, and the crystal components in urine were detected. Results As compared withcontrol group and stone-lnducing group, the calcium and oxalate in urine were increased significantly inVitamin D group, while the magnesium and citrate were decreased significantly (P<0. 05). The oxalate in urine of Vitamin K group was decreased significantly as compared with that of stone-inducinggroup (P <0. 05). Conclusions Vitamin D may promote stone formation through various mechanisms, whereas Vitamin K could inhibit this process. |
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| Keywords: | Kidney calculi Vitamin D_3 Vitamin K Animal model |
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