羟基磷灰石/聚DL乳酸内固定材料对骨折愈合的影响

目的 评价自行研制的可吸收羟基磷灰石／聚ＤＬ乳酸（ＨＡ／ＰＤＬＬＡ）复合内固定材料对实验性松质骨骨折愈合的影响。方法 取２５只兔作右股骨髁松质骨横形截骨，用ＨＡ／ＰＤＬＬＡ棒内固定。术后１、２、４、６和１２周作Ｘ线摄片、组织学和超微结构观察。结果 骨折均在６周内愈合，无炎性细胞聚集。经航向间观察可见多形核白细胞和巨噬细胞１周时较多，２周时减少，炎症期和清扫期未见明显延长；２周时以成纤维细胞为主，４

Effect of absorbable hydroxyapatite/poly DL lactide rods on experimental fracture healing

Objective To investigate the effect of self designed absorbable hydroxyapatite/poly DL lactide (HA/PDLLA) rods on experimental fracture healing. Methods 25 rabbits with a transverse transcondylar osteotomy of the distal femur were fixed intrameduallarily by a HA/PDLLA rod (diameter, 4.5 mm; length, 30 to 40 mm), and 1,2,4,6 and 12 weeks after operation, roentgenographic, histologic and ultrastructural analyses were done. Results A fracture healed within 6 weeks without delay, having no accumulation of inflammatory cells. Many polymorphonuclear neutrophils and macrophages existed at first week, but only few at 2nd week. The duration of the inflammatory and debridement stage were not obviously prolonged. There were many active fibroblasts at 2nd week. The cellularity at 4 week mainly included osteoblasts and osteocytes. At 6th week, some osteocytes tended to be static state. Conclusion HA/PDLLA rods possess a good biocompatibility to guarantee the normal union of the fracture of cancellous bone.