| 左旋精氨酸对急性胰腺炎的作用 |
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| 引用本文： | 李广阔,张肇达,刘续宝.左旋精氨酸对急性胰腺炎的作用[J].中华实验外科杂志,1999,16(2):161-163. |
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| 作者姓名： | 李广阔 张肇达 刘续宝 |
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| 作者单位： | 成都军区总医院全军普通外科中心!６１００８３(李广阔)，华西医科大学附属第一医院普外科(张肇达，刘续宝)，华西医科大学附属第一医院肾病科(郭月瑜) |
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| 摘 要： | 探讨左旋精氨酸（Ｌ－Ａｒｇ）在大鼠急性水肿性胰腺炎（ＡＥＰ）中的作用。方法观察倍数剂量Ｌ－Ａｒｇ治疗ＡＥＰ大鼠后，血浆和胰组织一氧化氮（ＮＯ）浓度、血浆淀粉酶、平均动脉压（ＭＡＰ）、胰组织病理的变化。结果ＡＥＰ大鼠血浆、胰组织ＮＯ浓度明显降低，Ｌ－Ａｒｇ５０、１００ｍｇ／ｋｇ升高血浆、胰组织ＮＯ浓度，改善了大鼠ＡＥＰ；Ｌ－Ａｒｇ８００、１６００ｍｇ／ｋｇ体重使ＮＯ浓度过度升高，加重ＡＥＰ成为急性出血坏死性胰腺炎（ＡＨＮＰ）；胰组织病理评分与血浆、胰组织ＮＯ浓度呈正相关。Ｌ－Ａｒｇ对ＭＡＰ的影响较小。血浆淀粉酶除８００ｍｇ／ｋｇ体重组明显降低外，其余各组间无明显差异。结论Ｌ－Ａｒｇ因升高ＮＯ浓度而参与了大鼠ＡＥＰ的病理过程。
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| 关 键 词： | 急性胰腺炎 平均动脉压 左旋精氨酸 一氧化氮 |
The role of L-arginine in the treatment of acute edematous pancreatitis in rats |
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| LI Guangkuo,ZHANG Zhaoda,LIU Xubao,et al..The role of L-arginine in the treatment of acute edematous pancreatitis in rats[J].Chinese Journal of Experimental Surgery,1999,16(2):161-163. |
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| Authors: | LI Guangkuo ZHANG Zhaoda LIU Xubao |
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| Institution: | LI Guangkuo,ZHANG Zhaoda,LIU Xubao,et al. Department of General Surgery,First ciliated Hospital,WestChina University of Medical Sciences,Chengdu 610041 |
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| Abstract: | Objective To investigate the role of different doses of L-arginine in the treatment ofacute edematous pancreatitis in rat. Method The alterations of mean arterial pressure (MAP), serumamylase, nitric oxide in serum and pancreatic tissue, pancreatic pathohistology were studied. ResultContent of nitric oxide in serum and pancreatic tissue was correlated with the scores of pancreatic pathohistology significantly (r1=0. 48, r2=0. 63, P<0. 05). MAP was decreased and serum amylase increased, but didn't relate to the scores of pancreatic pathohistology. Conclusion L-arginine might beinvolved in the development of acute pancreatitis by increasing the content of nitric oxide. |
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| Keywords: | Acute pancreatitis Mean arterial pressure L-arginine Nitric oxide |
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