| 异搏定、能量合剂对小肠缺血再灌注损伤的保护作用 |
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| 引用本文： | 倪绍忠,陈国玉.异搏定、能量合剂对小肠缺血再灌注损伤的保护作用[J].中华实验外科杂志,1999,16(4):338-339. |
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| 作者姓名： | 倪绍忠 陈国玉 |
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| 作者单位： | 南京医科大学附属第一医院血管外科 |
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| 摘 要： | 目的研究不同肠系膜上动脉灌注液对缺血小肠功能改变的影响。方法制成兔小肠缺血再灌注模型。分别观察缺血即刻、完全阻断６０分钟和再灌注３０分钟时小肠组织线粒体游离Ｃａ２＋浓度和小肠组织ＡＴＰ含量结果完全阻断６０分钟时，异搏定组Ｃａ２＋浓度（２．９７６±０．４１０）ｎｍｏｌ／ｍｇ·ｐｒｏｔ及该组和能量合剂组ＡＴＰ含量（０．５６４±０．０９７，０．５９４±０．０９０）μｍｏｌ／ｇ干重明显优于生理盐水组（Ｐ＜０．０１）；再灌注３０分钟时，两组Ｃａ２＋浓度（２．４０１±０．３２３，３．８４７±０．６１０）ｎｍｏｌ／ｍｇ·ｐｒｏｔ和ＡＴＰ含量（０．８０６±０．１８４，０．７４９±０．２８０）μｍｏｌ／ｇ干重均优于生理盐水组（Ｐ＜０．０１）。结论异搏定和能量合剂可以显著改善缺血小肠的功能改变。
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| 关 键 词： | 异搏定 能量合剂 ATP Ca~(2＋) |
Protective effects of verapamil and energy compounds on the ischemia reperfusion injury of animal intestine |
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| NI Shaozhong,CHEN Guoyu.Protective effects of verapamil and energy compounds on the ischemia reperfusion injury of animal intestine[J].Chinese Journal of Experimental Surgery,1999,16(4):338-339. |
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| Authors: | NI Shaozhong CHEN Guoyu |
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| Institution: | NI Shaozhong,CHEN Guoyu. Department of Vascular Surgery,The First Affiliated Hospital,Nanjing Medical University,Nanjing 210029 |
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| Abstract: | Objective To study the changes of the functions of the ischemic small bowel with different supper mesenteric artery (SMA) perfusions. Methods The model of the small intestine ischemia reperfusion (I/R) injury was made in gray rabbits. Free calcium concentrations in mitochondria and the ATP contents in the small intestine were determined right at the ischemia, 60 min after SMA complete occlusion and 30 min after reperfusion respectively. Results As compared with control group, free calcium concentration in verapamil group, and the ATP content in verapamil group and energy compounds group were lower at the time of 1 h blockade ( P <0.01). Calcium concentrations and ATP contents in these two groups were higher than in control group ( P <0.01). Conclusion Verapamil and energy compounds had obvious protective effects on the function of ischemic small intestine. |
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| Keywords: | Verapamil Energy compounds Ca 2 ATP |
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