红色诺卡氏菌细胞壁骨架对小鼠膀胱癌的治疗作用

目的　探讨红色诺卡氏菌细胞壁骨架（ＮＣＷＳ）对膀胱肿瘤的治疗效果及其机理。方法　观察皮下注射ＮＣＷＳ对小鼠同系移植膀胱癌的抗癌效应和ＮＣＷＳ对细胞免疫因子的影响。结果　给予ＮＣＷＳ的小鼠与肿瘤对照组比较肿瘤消退率为４１ ．６７ ％ ，抑瘤率为９６ ．２ ％ ；ＮＣＷＳ组ＩＬ１ 、ＩＬ２、ＩＬ６ 及ＮＫ 细胞活性和部分Ｔ细胞亚群则明显高于肿瘤对照组，但未能达到正常对照组的水平。结论ＮＣＷＳ对膀胱癌具有明显的抗癌效应，其机理为通过提高机体的ＩＬ１ 、ＩＬ２ 、ＩＬ６ 水平和ＮＫ 的活性及部分Ｔ 细胞亚群，提高机体的抗肿瘤免疫能力。

The inhibitory effects of N CWS on bladder carcinoma and the immune mechanism in mice

Objective To evaluate the effect and mechanics of Nocardia rubra cell wall skeleton (N CWS) in the treatment of bladder carcinoma in mice. Methods After subcutaneous injection of N CWS, the anti tumor effects of N CWS and the influence of N CWS on IL 1, IL 2, IL 6, T lymphocyte subgroup and the activity of NK were studied on transplanted bladder carcinoma (BST 739 ) in syngeneic T 739 mice. Results The tumor inhibition rate in the mice treated with N CWS was 96.2%. The levels of IL 1, IL 2, IL 6 and the activity of NK in the mice treated with N CWS was higher than those in tumor control mice. Conclusion N CWS, as an immune promoter, had obvious anti tumor effects on bladder carcinoma. The mechanism may be that the levels of IL 1, IL 2, IL 6, NK activity and part T lymphocyte subgroups, and human anti tumor immunological function are increased by N CWS.