A study of the dipeptidylpeptidase IV activity in cat fungiform papillae: light and electron microscope histochemistry |
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| Authors: | P Dubovy |
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| Institution: | 1. Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, 90-237, Poland;2. Biological Anthropology and Comparative Anatomy Research Unit, School of Medicine, The University of Adelaide, South Australia 5005, Australia;3. The Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland;4. BBMRI.pl Consortium, Wrocław, Poland;2. Graduate Program in Cell Biology, Stem Cells and Development, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA;3. Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA;4. Departments of Orofacial Sciences and Pediatrics, University of California San Francisco, San Francisco, California, USA;5. Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, USA |
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| Abstract: | The present paper describes histochemical study of the dipeptidylpeptidase IV activity in the nerve structures of cat fungiform papillae at the light and electron microscope levels. The dipeptidylpeptidase IV activity was found in blood vessels and nerve bundles entering the connective tissue stroma of fungiform papillae. The taste buds exhibited a moderate staining for the dipeptidylpeptidase IV activity. Ultracytochemical findings revealed this enzyme as membrane-bound in the endothelium of blood vessels, in plasma membrane of the Schwann cells at the axon-Schwann cell interface as well as in the taste bud cells. A possible function of the dipeptidylpeptidase IV activity in the peripheral nerve structures is discussed in view of the ability of this enzyme to cleave the substance P to the minor fragments with inherent physiological roles. |
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