| 鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系 |
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| 引用本文： | 杨开颜,俞康,李剑敏,黄卡特. 鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系[J]. 癌变．畸变．突变, 2003, 15(4): 215-216. DOI: 10.3969/j.issn.1004-616x.2003.04.008 |
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| 作者姓名： | 杨开颜 俞康 李剑敏 黄卡特 |
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| 作者单位： | 温州医学院附属一院病理科,浙江,温州,325000;温州医学院附属一院血液科,浙江,温州,325000 |
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| 摘 要： | 目的：探讨鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系。方法： 用免疫组化及TUNEL方法检测45例鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系。结果： 鳞癌Fas/FasL表达高于基底细胞癌；Fas/FasL阳性细胞凋亡率高于阴性细胞。 结论： Fas/FasL系统与细胞凋亡密切相关，并在肿瘤侵袭中可能起重要作用。
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| 关 键 词： | 鳞状细胞癌 基底细胞癌 凋亡 Fas/FasL |
| 文章编号： | 1004-616X(2003)04-0215-02 |
| 收稿时间： | 2003-02-06 |
| 修稿时间： | 2003-02-06 |
THE RELATIONSHIP BETWEEN Fas/FasL EXPRESSION IN SQUAMOUS CELL CARCINOMA, BASAL CELL CARCINOMA AND CELL APOPTOSIS |
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| YANG Kai-yan,YU Kang,LI Jian-min,et al. THE RELATIONSHIP BETWEEN Fas/FasL EXPRESSION IN SQUAMOUS CELL CARCINOMA, BASAL CELL CARCINOMA AND CELL APOPTOSIS[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2003, 15(4): 215-216. DOI: 10.3969/j.issn.1004-616x.2003.04.008 |
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| Authors: | YANG Kai-yan YU Kang LI Jian-min et al |
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| Affiliation: | 1.Department of Pathology The First Hospital of Wenzhou Medical College , Wenzhou 325000, China. 2. Deaertment of Hematology The First A ffiliated Hospital of Wenzhou Medical College , Wenzhou 325000, China |
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| Abstract: | Purpose: To explore the relationship between Fas/FasL expression in squamous cell carcinoma, basal cell carcinoma or cell apoptosi. Methods: Fas/FasL expression and cell apoptosis were studied in 45 patients suffering from squamous cell carcinoma or basal cell carcinoma by immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP-DIG nick end labeling (TUNEL). Results: Fas/FasL expression in squamous cell carcinoma was higher than in basal cell carcinoma. The apoptosis rate of Fas/FasL positive cells was higher than that of Fas/FasL negative cells. Conclusion: Fas/FasL system was rather associated with cell apoptosis and may play an important role in tumor invasion. |
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| Keywords: | squamous cell carcinoma basal cell carcinoma apoptosis Fas/FasL |
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