| 特发性血小板减少性紫癜发病机制的研究现况 |
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| 引用本文： | 赵雪芸,贾瑞萍.特发性血小板减少性紫癜发病机制的研究现况[J].医学综述,2009,15(15):2277-2280. |
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| 作者姓名： | 赵雪芸 贾瑞萍 |
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| 作者单位： | 1. 包头医学院,内蒙古,包头,014040
2. 包头市中心医院血液内科,内蒙古,包头,014040 |
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| 摘 要： | 特发性血小板减少性紫癜(ITP)是一种常见的出血性自身免疫病,其发病机制尚未完全明了。目前认为ITP的原因主要是人体自身免疫耐受机制被打破,体液免疫和细胞免疫紊乱,导致血小板破坏增加和(或)生成障碍。淋巴细胞是维持机体免疫功能的主要细胞群,其凋亡和增殖平衡被打破,就会导致免疫功能紊乱,进而形成自身免疫性疾病。本文对特发性血小板减少性紫癜发病机制的研究现况予以综述。
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| 关 键 词： | 血小板减少性紫癜 特发性 发病机制 感染 免疫 |
Research Progress of Idiopathic Thrombocytopenic Purpura |
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| ZHAO Xue-yun,JIA Rui-ping.Research Progress of Idiopathic Thrombocytopenic Purpura[J].Medical Recapitulate,2009,15(15):2277-2280. |
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| Authors: | ZHAO Xue-yun JIA Rui-ping |
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| Institution: | ZHAO Xue-yun , JIA Ruioping ( 1. Baotou Medical College, Baotou 014040, China ;2. Department of Hematology, Baotou Central Hospital, Baotou 014040, China) |
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| Abstract: | Idiopathic thrombocytopenic purpura（ITP） is a common hemorrhagic autoimmune disease,but the pathogenesis remains unclear. ITP is mainly caused by the broken immune tolerance and the increase of platelet destruction and/or generate obstacles. Lymphocytes are the major ceil groups in maintaining the immune function. The balance between apoptosis and proliferation of lymphocytes is broken in vivo,which causes the immune function disorders and autoimmune diseases. This article reviewed the research progress of ITP. |
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| Keywords: | Thrombocytopenic purpura Idiopathic Pathogenesis Infection Immunity |
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