乙二醇对大鼠睾丸和附睾中某些酶的影响

研究了乙二醇对大鼠睾丸和附睾中某些酶的影响。Ｗｉｓｔａｒ雄性大鼠，乙二醇连续灌胃染毒１３周，剂量分别为６６６，１３３２和２６６４ｍｇ／ｋｇ。结果表明，所有染毒组大鼠睾丸中ＬＤＨ（ＬＤＨ－Ｘ）酶活性均明显下降；剂量为１３３２ｍｇ／ｋｇ染毒组，引起ＡＣＰ和ＡＫＰ酶活性明显下降，但对γ－ＧＴ酶活性无明显作用。低剂量时乙二醇就能引起附睾中ＬＤＨ，γ－ＧＴ，ＡＣＰ和ＡＫＰ酶活性明显升高。结果提示，乙二醇对睾丸中ＬＤＨ（ＬＤＨ－Ｘ），ＡＣＰ和ＡＫＰ均有影响，其中ＬＤＨ（ＬＤＨ－Ｘ）酶活性对乙二醇的毒性较敏感。此外，乙二醇对附睾中这些酶活性也有非常显著的影响，表现为小剂量刺激，高剂量抑制。

Effect of ethylene glycol on several enzymes of testis and epididymins in rats

The research to evaluate the effect of ethylene glycol on the activities of LDH (LDHX) ,AKP, ACP and r-GT of testis and epididymis in rats was conducted. The male rats were administered ethylene glycol by gavage 6 times a week for 13 weeks at the dose of 0,666 , 1332 or 2664mg/kg body weight.The results indicated that the treatment caused a decrease in activities of LDH (LDHX) in testis of the male rats at and over the dose level of 666mg/kg. The decreases in activities of ACP and AKP were observed in the male rats at and over the dose level of 1332mg/kg, but there was no change in activity of r-GT. Marked increase in activities of LDH,AKP, ACP and r-GT in epididymis were observed in low dose group. The results indicate that ethylene glycol has effect on LDH (LDH-X) ,AKP and ACP. The LDH (LDH-X) is the most susceptable to the toxicity of ethylene glycol. The effects of ethylene glycol on LDH, AKP , ACP and r-GT in epididymis of the male rats were also noted.