Autism genetic database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites |
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Authors: | Gregory Matuszek Zohreh Talebizadeh |
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Institution: | (1) K-INBRE Bioinformatics Core Facility, University of Kansas, Lawrence, KS, USA;(2) Section of Medical Genetics and Molecular Medicine, Children's Mercy Hospitals and University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA |
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Abstract: | Background Autism is a highly heritable complex neurodevelopmental disorder, therefore identifying its genetic basis has been challenging.
To date, numerous susceptibility genes and chromosomal abnormalities have been reported in association with autism, but most
discoveries either fail to be replicated or account for a small effect. Thus, in most cases the underlying causative genetic
mechanisms are not fully understood. In the present work, the Autism Genetic Database (AGD) was developed as a literature-driven,
web-based, and easy to access database designed with the aim of creating a comprehensive repository for all the currently
reported genes and genomic copy number variations (CNVs) associated with autism in order to further facilitate the assessment
of these autism susceptibility genetic factors. |
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Keywords: | |
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