呼吸重症病房肺部感染的病原菌分布及其耐药性研究

目的：探究重症病房肺部感染患者的病原菌分布特点及其耐药性。方法：选择210例呼吸重症病房肺部感染患者作为研究对象，分析患者痰液标本、呼吸道分泌物、支气管灌洗液中的病原菌，并统计其分布特点，对主要病原菌进行相应的药敏试验。结果：本组研究共分离122株病原菌，其中肺炎克雷伯菌30株（24．59％），大肠埃希菌16株（13．11％），均明显高于其他病原菌，且与其他病原菌之间的差异显著且具有统计学意义（P〈0．05）；大肠埃希菌与肺炎克雷伯菌对磺胺甲嗯唑／甲氧苄啶的耐药性最高，其耐药率分别为87．50％、76．67％，明显高于对其他抗菌药物的耐药率，且其差异具有统计学意义（P〈0．05）。结论：本研究中呼吸重症病房肺部感染以大肠埃希菌、肺炎克雷伯菌为主，且这两种病原菌对磺胺甲嗯唑／甲氧苄啶耐药性最高，临床治疗时应密切观察病原菌培养及病原菌的耐药性，并依据药敏结果选择适宜的药物，以提高提高抗感染治疗的成功率，并促进患者尽早康复。

Distribution and drug resistance of pathogenic bacteria of pulmonary infection in respiratory ICU

Objective： To explore the ICU patients with lung infection pathogen distribution and drug resistance. Methods： 210 cases of pulmonary infection in respiratory ICU patients as the research objects, analysis of pathogenic bacteria in sputum samples from patients with respiratory secretions, in bronchial lavage fluid, and its distribution characteristics, statistical, drug sensitive tests were made on the main pathogenic bacteria. Results： in this group, 122 strains of pathogenic bacteria were isolated, including 30 strains of Klebsiella pneumoniae （24.59%）, Escherichia coli 16 strains （13.11%） were significantly higher than those of other pathogenic bacteria, and the differences with other pathogens significantly and have statistical significance （P〈0.05）; drug resistance of Escherichia coli and Klebsiella pneumoniae to sulfamethoxazole / trimethoprim is the highest, and the resistant rate were 87.50%, 76.67%, significantly higher than that of other antimicrobial resistance rate, and the difference was statistically significant （P〈0.05）. Conclusion： Respiratory ICU pulmonary infection with Escherichia coli, Klebsiella pneumonia mainly in this. research, and these two kinds of pathogenic bacteria to sulfamethoxazole / trimethoprim resistance is highest, the treatment should closely observe the bacteria culture and drug resistance of pathogenic bacteria, and according to the results of drug susceptibility for appropriate choice of drugs, in order to improve the to improve the anti infection treatment success rate, and promote the patient recover early.