| 葛根素注射液在家兔体内的药动学研究 |
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| 引用本文： | 莫凡,肖学凤,乔晓莉,高岚,孙瑜.葛根素注射液在家兔体内的药动学研究[J].天津中医药大学学报,2009,28(4):204-206. |
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| 作者姓名： | 莫凡 肖学凤 乔晓莉 高岚 孙瑜 |
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| 作者单位： | 1. 天津中医药大学,300193
2. 天津市南开医院,300100 |
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| 摘 要： | 目的]研究葛根素注射液在家兔体内的药动学规律.方法]家兔耳缘静脉注射葛根素注射液后,采用高效液相色谱法测定血浆中葛根素的含量.结果]葛根素的血药浓度一时间曲线符合三室开放模型,其主要药动学参数分别为消除相半衰期(t1/2β)=1.33 h,血药浓度-时间曲线下面积(AUC)=13.0(mg/L)·h,消除率CL(S)]=6.16mg/kg/h/(mg·L).结论]明确了葛根素在家兔体内的药动学特征.
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| 关 键 词： | 葛根素 高效液相色谱 药动学 |
| 收稿时间： | 9/9/2009 12:00:00 AM |
Study on pharmacokinetics of puerarin injection in rabbits |
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| Mo Fan,Xiao Xue-feng,Qiao Xiao-li.Study on pharmacokinetics of puerarin injection in rabbits[J].Journal of Tianjin University of Traditonal Chinese Medicine,2009,28(4):204-206. |
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| Authors: | Mo Fan Xiao Xue-feng Qiao Xiao-li |
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| Institution: | Tianjin University of TCM, Tianjin 300193, China;Tianjin University of TCM, Tianjin 300193, China;Tianjin University of TCM, Tianjin 300193, China;Tianjin University of TCM, Tianjin 300193, China |
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| Abstract: | Objective] To observe the pharmacokinetic characteristics of Puerarin injection in rabbits. Methods] After giving of injection of Puerarin i.v.into rabbits,HPLC was used to determine the puerarin levels in the biological samples.Results] The plasma concentration-time course of puerarin fitted well to one-compartment model and with the following pharmacokinetic parameters:Ke=0.02min-1,t1/2ke=35.66min,AUC=495.27 (mg/kg) omin.Conclusion] The pharmacokinetic characteristics of puerarin in rabbits was understood. |
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| Keywords: | Puerarin HPLC Pharmacokinetic |
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