Endothelial Regulation of Vascular Repair: Role of bFGF in Paracrine Pathways |
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| Authors: | Gotlieb Avrum I. |
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| Affiliation: | (1) Vascular Research Laboratory, Banting and Best Diabetes Centre, The Toronto Hospital, Toronto, Canada;(2) Department of Pathology, University of Toronto, Toronto, Canada;(3) Centre for Cardiovascular Research, University of Toronto, Toronto, Canada;(4) Vascular Research Laboratory, The Toronto Hospital Research Institute, 200 Elizabeth Street, CCRW 1-857, M5G 2C4 Toronto, Ontario, Canada |
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| Abstract: | Vascular repair following injury is mediated by both endothelial and smooth muscle cells often through paracrine pathways. Basic fibroblast growth factor (bFGF) is present at sites of vascular injury. The role of bFGF in regulating reendothelialization through an effect on centrosome redistribution in cell migration is discussed. The role of bFGF in neointimal formation, especially as it relates to smooth muscle cell proliferation, is reviewed. It is concluded that bFGF appears to be an important agent regulating the early responses of the artery wall to injury. Presented in part at the Molecular Endocrine Pathology Symposium at the International Academy of Pathology XXI International Congress, Budapest, Hungary, October 20–25, 1996. |
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| Keywords: | Endothelium hemodynamic shear stress atherosclerosis centrosomes actin microfilaments microtubules neointima smooth muscle cells |
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