Fatal infectious mononucleosis with staphylococcal pyoderma in a girl with hereditary immunological dysregulations |
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| Authors: | T Inaba R Hanada A Yaginuma Y Hayashi K Yamamoto H Hukada |
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| Institution: | (1) Division of Haematology/Oncology, Saitama Children's Medical Center, 2100 Magome Iwatsuki, 339 Saitama, Japan;(2) Division of Dermatology, Saitama Children's Medical Center, 2100 Magome Iwatsuki, 339 Saitama, Japan |
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| Abstract: | We describe a 14-year-old girl with fatal infectious mononucleosis with high fever, pancytopenia, and multiple skin ulcers due toStaphylococcus aureus. Immunological studies revealed low serum IgM, low natural killer (NK) activity, and high CD4/CD8 ratio. Her father had also low NK activity and high CD4/CD8 ratio. It is suggested that she had a dominantly inherited immunodeficiency predisposing to severe Epstein-Barr virus infection. |
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| Keywords: | Fatal infectious mononucleosis Staphylococcal pyoderma Immunodysregulation |
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